Production and Use of the First-Row Transition Metal PET Radionuclides 43,44Sc, 52Mn, and 45Ti

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FIGURE 1.
Results of ⁵²Mn-DOTA-TRC105 injection into 4T1 xenograft tumor–bearing mice. %ID = percentage injected dose. (Reprinted with permission from (34).)
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FIGURE 2.
Miniature Derenzo phantom image (3.7 MBq of ⁴⁵Ti; image taken after 60-min scan time).

TABLE 1

⁴³Sc Production Routes Highlighted by Walczak et al. (9)

TABLE 2

⁵²Mn Separation Methods

Resin	Target dissolution	Target material eluent	^52gMn eluent	Reference
Dowex^* 50 WX8	1 mL of fuming HCl	0.1 M H₂SO₄	0.067 M ammonium citrate, pH 7.3–7.4	(33)
AG^† 1-X8	11.3 M HCl	5 mL of 0.1 M HCl, 10 mL of H₂O, 3% (v/v) 11.3 M HCl	2 mL 0.1 M HCl	(29,32,35,36)
AG^† 50W-X8	Diluted HCl	0.1 M sulfuric acid	6 M HCl	(38)
AG^† 1-X8, organic extraction	12.1 M HCl	Chromium ions remained in aqueous phase	10 mL 0.8 M trioctylamine in cyclohexane, organic phase	(32)