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Table 1. Effects of PD-L1 mAb dose escalation on Zr-89 PD-L1 mAb Tissue:Muscle ratios
Tissue: Muscle Ratios 3 d post injection [mean (SD); n=5,6] PD-L1 mAb dose (ug) [coinjected with Zr-89 PD-L1 mAb (2 ug) ] 0 10 20 40 400 Spleen 42.6 (8.4) 39.5 (10.8) 23.6 (3.5) 9.2 (1.8) 4.4 (0.4) Lymph nodes 9.4 (1.6) 11.3 (3.9) 43.3 (9.7) 19.4 (4.4) 11.5 (2.2) MDA-MB231 tumor 3.1 (0.6) 2.2 (0.4) 10.6 (2.1) 10.0 (1.7) 8.9 (2.3)
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