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Meeting ReportOncology, Basic Science Track

Imaging adult glioma with 68Ga-citrate PET/MR

Michael Evans, Spencer Behr, Yan Li and Javier Villanueva-Meyer
Journal of Nuclear Medicine May 2018, 59 (supplement 1) 1275;
Michael Evans
1Radiology and Biomedical Imaging UCSF San Francisco CA United States
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Spencer Behr
2University of California - San Francisco San Francisco CA United States
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Yan Li
1Radiology and Biomedical Imaging UCSF San Francisco CA United States
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Javier Villanueva-Meyer
1Radiology and Biomedical Imaging UCSF San Francisco CA United States
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Abstract

1275

Objectives: ninvasive tools that selectively target tumor cells could improve the management of primary brain tumors. Cancer generally has a high demand for Fe(III), an essential nutrient for a variety of biochemical processes. We tested whether preclinical models and clinical high grade glioma can be detected with PET/MR using 68Ga(IV), a Fe(III) biomimetic that binds to transferrin in blood. Preclinical animal studies showed that 68Ga(IV) accumulated in U87MG, a model of high grade glioma, in a transferrin receptor-dependent fashion within 4 hours post injection. All normal tissues, including the brain, had comparatively lower radiotracer uptake, with the exception of bone. Subsequently, fourteen patients with WHO grade III or IV glioma received 3.7 - 10 mCi of 68Ga-citrate and were imaged with PET/MR 102 - 303 minutes post injection. Multiple contrast-enhancing lesions were PET avid, while normal brain tissue was not. Several contrast-enhancing lesions were not PET avid, which suggests a receptor mediated mechanism of tumor uptake, rather than nonspecific accumulation in regions with aberrant vasculature. One minimally enhancing tumor and a tumor with significantly reduced enhancement post treatment with bevacizumab were PET avid. These early data demonstrate that high-grade glioma is detectable with a radiotracer targeted to its molecular characteristics. Further studies are being performed to establish the role of this novel imaging technique in the management of patients.

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Journal of Nuclear Medicine
Vol. 59, Issue supplement 1
May 1, 2018
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Imaging adult glioma with 68Ga-citrate PET/MR
Michael Evans, Spencer Behr, Yan Li, Javier Villanueva-Meyer
Journal of Nuclear Medicine May 2018, 59 (supplement 1) 1275;

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Imaging adult glioma with 68Ga-citrate PET/MR
Michael Evans, Spencer Behr, Yan Li, Javier Villanueva-Meyer
Journal of Nuclear Medicine May 2018, 59 (supplement 1) 1275;
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