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Research ArticleOncology

Rate of Distant Metastases on 18F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years

Vincent Lebon, Jean-Louis Alberini, Jean-Yves Pierga, Véronique Diéras, Nina Jehanno and Myriam Wartski
Journal of Nuclear Medicine February 2017, 58 (2) 252-257; DOI: https://doi.org/10.2967/jnumed.116.178749
Vincent Lebon
1Service de Médecine Nucléaire, Institut Curie, Paris, France
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Jean-Louis Alberini
2Service de Médecine Nucléaire, Institut Curie, Saint-Cloud, France
3Faculté de Médecine, Université Versailles Saint-Quentin, Versailles, France
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Jean-Yves Pierga
4Département d’Oncologie Médicale, Institut Curie, Paris, France; and
5Faculté de Médecine, Université Paris-Descartes, Paris, France
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Véronique Diéras
4Département d’Oncologie Médicale, Institut Curie, Paris, France; and
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Nina Jehanno
1Service de Médecine Nucléaire, Institut Curie, Paris, France
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Myriam Wartski
1Service de Médecine Nucléaire, Institut Curie, Paris, France
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  • FIGURE 1.
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    FIGURE 1.

    18F-FDG PET/CT at initial staging in 35-y-old patient with invasive ductal carcinoma of left breast, classified as clinical stage IIA disease. (A) Maximum-intensity projection. (B–D) Axial PET/CT fusion images showing cervical (B) and mediastinal (C) lymph node and bone (D) metastases.

  • FIGURE 2.
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    FIGURE 2.

    18F-FDG PET/CT at initial staging in 46-y-old patient with invasive ductal carcinoma of right breast, classified as clinical stage IIIA disease. (A) Maximum-intensity projection. (B–D) Axial PET/CT fusion images showing liver (B and C) and bone (D) metastases.

Tables

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    TABLE 1

    Characteristics of Patients and Tumors at Diagnosis

    Group
    Characteristic<40 y old≥40 y oldP
    No. of patients107107
    Age (y)*34.5 ± 4.056.0 ± 10.7
    AJCC stage before PET/CT
     I12 (11)12 (11)
     IIA32 (30)32 (30)
     IIB30 (28)30 (28)
     III33 (31)33 (31)
    Tumor type
     Invasive ductal95 (89)86 (80)0.13
     Invasive lobular1 (1)9 (8)0.02
     Other11 (10)12 (11)
    Tumor grade
     13 (3)10 (9)0.08
     226 (24)42 (39)0.03
     378 (73)55 (51)0.002
    Receptor phenotype
     HR+/HER2−36 (34)53 (50)0.03
     HER2+35 (33)26 (24)0.23
     TNBC35 (33)28 (26)0.37
     Unspecified1 (1)
    • ↵* Reported as mean ± SD.

    • AJCC = American Joint Committee on Cancer.

    • Data are reported as number (percentage) of patients unless otherwise indicated.

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    TABLE 2

    Numbers of Patients with Distant Metastases on 18F-FDG PET/CT

    Group
    AJCC stage before PET/CT (no. of patients)<40 y old≥40 y oldP
    I (12)1 (8)1 (8)1
    IIA (32)3 (9)4 (13)1
    IIB (30)5 (17)4 (13)1
    III (33)14 (42)15 (45)1
    All (107)23 (21)24 (22)1
    • AJCC = American Joint Committee on Cancer.

    • Data are reported as number (percentage) of patients.

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Journal of Nuclear Medicine: 58 (2)
Journal of Nuclear Medicine
Vol. 58, Issue 2
February 1, 2017
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Rate of Distant Metastases on 18F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years
Vincent Lebon, Jean-Louis Alberini, Jean-Yves Pierga, Véronique Diéras, Nina Jehanno, Myriam Wartski
Journal of Nuclear Medicine Feb 2017, 58 (2) 252-257; DOI: 10.2967/jnumed.116.178749

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Rate of Distant Metastases on 18F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years
Vincent Lebon, Jean-Louis Alberini, Jean-Yves Pierga, Véronique Diéras, Nina Jehanno, Myriam Wartski
Journal of Nuclear Medicine Feb 2017, 58 (2) 252-257; DOI: 10.2967/jnumed.116.178749
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Keywords

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