Relationship between the dynamic profile of LAT1 probe and tumoral blood flow: comparison study using 18F-FBPA, 18F-FAMT, and 15O-water PET

Masanao Aoki; Tadashi Watabe; Shushi Nagamori; Hayato Ikeda; Genki Horitsugi; Sadahiro Naka; Yasukazu Kanai; Hiroki Kato; Eku Shimosegawa; Yoshikatsu Kanai; Jun Hatazawa

Meeting ReportOncology, Basic Science Track

Relationship between the dynamic profile of LAT1 probe and tumoral blood flow: comparison study using ¹⁸F-FBPA, ¹⁸F-FAMT, and ¹⁵O-water PET

Masanao Aoki, Tadashi Watabe, Shushi Nagamori, Hayato Ikeda, Genki Horitsugi, Sadahiro Naka, Yasukazu Kanai, Hiroki Kato, Eku Shimosegawa, Yoshikatsu Kanai and Jun Hatazawa

Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1346;

Masanao Aoki

7Osaka-University Suita Japan

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Tadashi Watabe

6Nuclear Medicine and Tracer Kinetics Osaka University Graduate School of Medicine Suita Japan

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Shushi Nagamori

5Bio-System Pharmacology Osaka University Graduate School of Medicine Suita Japan

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Hayato Ikeda

2Department of Nuclear Medicine and Tracer Kinetics Osaka University Suita Japan

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Genki Horitsugi

1Osaka Japan

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Sadahiro Naka

4Osaka University Graduate School of Medicine Suita Japan

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Yasukazu Kanai

4Osaka University Graduate School of Medicine Suita Japan

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Hiroki Kato

1Osaka Japan

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Eku Shimosegawa

4Osaka University Graduate School of Medicine Suita Japan

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Yoshikatsu Kanai

5Bio-System Pharmacology Osaka University Graduate School of Medicine Suita Japan

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Jun Hatazawa

3Osaka University Graduate School of Medicine Suita, Osaka Japan

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Tumoral blood flow volume
MIAPaCa Glioma ratio (Glioma / MIAPaCa)
K1 (ml/ccm/min) 0.31 0.93 3.04
k2 (1/min) 0.42 1.51 3.63
SUV at 10 min in malignant tumors
MIAPaCa Glioma ratio (Glioma / MIAPaCa)
FAMT 1.11 3.20 2.88
FBPA 1.11 3.17 2.87

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Journal of Nuclear Medicine

Vol. 57, Issue supplement 2

May 1, 2016

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Relationship between the dynamic profile of LAT1 probe and tumoral blood flow: comparison study using ¹⁸F-FBPA, ¹⁸F-FAMT, and ¹⁵O-water PET

Masanao Aoki, Tadashi Watabe, Shushi Nagamori, Hayato Ikeda, Genki Horitsugi, Sadahiro Naka, Yasukazu Kanai, Hiroki Kato, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa

Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1346;

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Relationship between the dynamic profile of LAT1 probe and tumoral blood flow: comparison study using ¹⁸F-FBPA, ¹⁸F-FAMT, and ¹⁵O-water PET

Masanao Aoki, Tadashi Watabe, Shushi Nagamori, Hayato Ikeda, Genki Horitsugi, Sadahiro Naka, Yasukazu Kanai, Hiroki Kato, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa

Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1346;

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Relationship between the dynamic profile of LAT1 probe and tumoral blood flow: comparison study using ¹⁸F-FBPA, ¹⁸F-FAMT, and ¹⁵O-water PET

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	MIAPaCa	Glioma	ratio (Glioma / MIAPaCa)
K1 (ml/ccm/min)	0.31	0.93	3.04
k2 (1/min)	0.42	1.51	3.63

	MIAPaCa	Glioma	ratio (Glioma / MIAPaCa)
FAMT	1.11	3.20	2.88
FBPA	1.11	3.17	2.87