GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo

Parmanand Singh; Silvia González-Ramos; Marina Mojena; César Eduardo Rosales-Mendoza; Hamed Emami; Jeffrey Swanson; Alex Morss; Zahi A. Fayad; James H.F. Rudd; Jeffrey Gelfand; Marta Paz-García; Paloma Martín-Sanz; Lisardo Boscá; Ahmed Tawakol

doi:10.2967/jnumed.115.167387

Research ArticleBasic Science Investigations

GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo

Parmanand Singh, Silvia González-Ramos, Marina Mojena, César Eduardo Rosales-Mendoza, Hamed Emami, Jeffrey Swanson, Alex Morss, Zahi A. Fayad, James H.F. Rudd, Jeffrey Gelfand, Marta Paz-García, Paloma Martín-Sanz, Lisardo Boscá and Ahmed Tawakol

Journal of Nuclear Medicine September 2016, 57 (9) 1428-1435; DOI: https://doi.org/10.2967/jnumed.115.167387

Parmanand Singh

1Cardiology Division, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York

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Silvia González-Ramos

2Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC-UAM, Madrid, Spain

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Marina Mojena

2Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC-UAM, Madrid, Spain

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César Eduardo Rosales-Mendoza

2Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC-UAM, Madrid, Spain

3Departamento de Bioquímica y Medicina Molecular, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México

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Hamed Emami

4Cardiac MR PET CT Program, Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

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Jeffrey Swanson

4Cardiac MR PET CT Program, Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

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Alex Morss

4Cardiac MR PET CT Program, Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

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Zahi A. Fayad

5Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York

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James H.F. Rudd

6Division of Cardiovascular Medicine, University of Cambridge, Cambridge, United Kingdom

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Jeffrey Gelfand

7Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and

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Marta Paz-García

2Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC-UAM, Madrid, Spain

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Paloma Martín-Sanz

2Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC-UAM, Madrid, Spain

8Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain

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Lisardo Boscá

2Instituto de Investigaciones Biomédicas “Alberto Sols,” CSIC-UAM, Madrid, Spain

8Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain

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Ahmed Tawakol

4Cardiac MR PET CT Program, Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

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September 1, 2016

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GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo

Journal of Nuclear Medicine Sep 2016, 57 (9) 1428-1435; DOI: 10.2967/jnumed.115.167387

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GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo

Journal of Nuclear Medicine Sep 2016, 57 (9) 1428-1435; DOI: 10.2967/jnumed.115.167387

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Keywords

18F-FDG-PET
glycolysis
GM-CSF
inflammation
macrophage

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