Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET

Ganesan Vaidyanathan; Darryl McDougald; Jaeyeon Choi; Eftychia Koumarianou; Douglas Weitzel; Takuya Osada; H. Kim Lyerly; Michael R. Zalutsky

doi:10.2967/jnumed.115.171306

Research ArticleBasic Science Investigations

Preclinical Evaluation of ¹⁸F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET

Ganesan Vaidyanathan, Darryl McDougald, Jaeyeon Choi, Eftychia Koumarianou, Douglas Weitzel, Takuya Osada, H. Kim Lyerly and Michael R. Zalutsky

Journal of Nuclear Medicine June 2016, 57 (6) 967-973; DOI: https://doi.org/10.2967/jnumed.115.171306

Ganesan Vaidyanathan

1Department of Radiology, Duke University Medical Center, Durham, North Carolina

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Darryl McDougald

1Department of Radiology, Duke University Medical Center, Durham, North Carolina

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Jaeyeon Choi

1Department of Radiology, Duke University Medical Center, Durham, North Carolina

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Eftychia Koumarianou

1Department of Radiology, Duke University Medical Center, Durham, North Carolina

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Douglas Weitzel

2Department of Radiation Oncology and Cancer Biology, Duke University Medical Center, Durham, North Carolina; and

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Takuya Osada

3Department of Surgery, Duke University Medical Center, Durham, North Carolina

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H. Kim Lyerly

3Department of Surgery, Duke University Medical Center, Durham, North Carolina

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Michael R. Zalutsky

1Department of Radiology, Duke University Medical Center, Durham, North Carolina

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Journal of Nuclear Medicine

Vol. 57, Issue 6

June 1, 2016

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Preclinical Evaluation of ¹⁸F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET

Ganesan Vaidyanathan, Darryl McDougald, Jaeyeon Choi, Eftychia Koumarianou, Douglas Weitzel, Takuya Osada, H. Kim Lyerly, Michael R. Zalutsky

Journal of Nuclear Medicine Jun 2016, 57 (6) 967-973; DOI: 10.2967/jnumed.115.171306

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Preclinical Evaluation of ¹⁸F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET

Ganesan Vaidyanathan, Darryl McDougald, Jaeyeon Choi, Eftychia Koumarianou, Douglas Weitzel, Takuya Osada, H. Kim Lyerly, Michael R. Zalutsky

Journal of Nuclear Medicine Jun 2016, 57 (6) 967-973; DOI: 10.2967/jnumed.115.171306

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Keywords

HER2
Nanobody
18F
immuno-PET
Residualizing label

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