Can an 18F-ALF-NOTA-PRGD2 PET/CT Scan Predict Treatment Sensitivity to Concurrent Chemoradiotherapy in Patients with Newly Diagnosed Glioblastoma?

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FIGURE 1.
¹⁸F-RGD PET/CT at baseline and 3 wk in nonresponding patient (A; patient 11; Table 2) and responding patient (B; patient 14; Table 2).
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FIGURE 2.
Comparison of ¹⁸F-RGD PET/CT and MRI at baseline and 3 wk (patient 19; Table 2).
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FIGURE 3.
ROC curves of parameters.

TABLE 1

Patient Characteristics

Characteristic	n
Total no.	25
Age (y)
Median	49.5
Range	30–64
Sex
Male	15 (60%)
Female	10 (40%)
Karnofsky performance score	80 (range, 70–90)
70–80	16
90–100	9
Pathology	GBM (World Health Organization, IV)
Surgery	Partial resection

TABLE 2

Tumor Response Comparison by Different Criteria in Patients with Newly Diagnosed Glioblastoma

ΔVOL_T1–3 was calculated by (VOL_T3 − VOL_T1)/VOL_T1 on MR images.
ΔVOL_T1–3 = change in lesion volume from T1 to T3 on MRI; SD = stable disease; PR = partial response; CR = complete response; PD = progressive disease.