@article {Zhang524, author = {Hui Zhang and Ning Liu and Song Gao and Xudong Hu and Wei Zhao and Rongjie Tao and Zhaoqiu Chen and Jinsong Zheng and Xiaorong Sun and Liang Xu and Wanhu Li and Jinming Yu and Shuanghu Yuan}, title = {Can an 18F-ALF-NOTA-PRGD2 PET/CT Scan Predict Treatment Sensitivity to Concurrent Chemoradiotherapy in Patients with Newly Diagnosed Glioblastoma?}, volume = {57}, number = {4}, pages = {524--529}, year = {2016}, doi = {10.2967/jnumed.115.165514}, publisher = {Society of Nuclear Medicine}, abstract = {This study examined the value of a novel 1-step labeled integrin αvβ3{\textendash}targeting 18F-AlF-NOTA-PRGD2 (denoted as 18F-RGD) scan in assessing sensitivity to concurrent chemoradiotherapy (CCRT) in patients with newly diagnosed glioblastoma multiforme (GBM). Methods: Twenty-five patients with newly diagnosed GBM were enrolled in this study 3{\textendash}5 wk after surgical resection. All participants were investigated with 18F-RGD PET/CT on baseline (T1) and at the third week (T2) after the start of CCRT. Tumor volume, maximal and mean standardized uptake value of the tumor (SUVmax, SUVmean), and tumor-to-nontumor ratios of the tumor volume were obtained. The MRI treatment response was assessed at the 11th week (T3). The change in the lesion volume from T1 to T3 on MRI was used as an endpoint to evaluate the predictive ability of 18F-RGD PET/CT. Results: With 18F-RGD PET/CT imaging, we successfully visualized the residual lesions of GBM. Twenty-five and 23 18F-RGD PET/CT scans at baseline and the third week, respectively, were available for analysis. We found that 18F-RGD PET/CT parameters, both pretreatment SUVmax on baseline (P \< 0.05) and intratreatment SUVmax at the third week (SUVmaxT2) (P \< 0.05) and tumor-to-nontumor ratios at the third week (P \< 0.05), were predictive of treatment sensitivity to CCRT. Additionally, the change of volume from T1 to T2 on MRI was also predictive (P \< 0.05). According to receiver-operating-characteristic curve analysis, the most significant parameter was SUVmaxT2 (area under the curve, 0.846). The threshold of SUVmaxT2 was 1.35, and its sensitivity, specificity, and accuracy were 84.6\%, 90.0\% and 87.0\%, respectively. Conclusion: 18F-RGD PET/CT allows for the noninvasive visualization of GBM lesions and the prediction of sensitivity to CCRT as early as 3 wk after treatment initiation.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/57/4/524}, eprint = {https://jnm.snmjournals.org/content/57/4/524.full.pdf}, journal = {Journal of Nuclear Medicine} }