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Research ArticleClinical Investigations

68Ga-DOTATATE PET/CT in the Localization of Head and Neck Paragangliomas Compared with Other Functional Imaging Modalities and CT/MRI

Ingo Janssen, Clara C. Chen, David Taieb, Nicholas J. Patronas, Corina M. Millo, Karen T. Adams, Joan Nambuba, Peter Herscovitch, Samira M. Sadowski, Antonio T. Fojo, Inga Buchmann, Electron Kebebew and Karel Pacak
Journal of Nuclear Medicine February 2016, 57 (2) 186-191; DOI: https://doi.org/10.2967/jnumed.115.161018
Ingo Janssen
1Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
2Section of Nuclear Medicine, Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany
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Clara C. Chen
3Nuclear Medicine Division, Radiology & Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
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David Taieb
4Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France
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Nicholas J. Patronas
5Section of Neuroradiology, Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
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Corina M. Millo
6Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
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Karen T. Adams
1Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
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Joan Nambuba
1Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
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Peter Herscovitch
6Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland
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Samira M. Sadowski
7Endocrine Oncology Branch, National Cancer Institute, Bethesda, Maryland; and
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Antonio T. Fojo
8Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
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Inga Buchmann
2Section of Nuclear Medicine, Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Lübeck, Germany
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Electron Kebebew
7Endocrine Oncology Branch, National Cancer Institute, Bethesda, Maryland; and
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Karel Pacak
1Program in Adult and Reproductive Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
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  • FIGURE 1.
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    FIGURE 1.

    Patient 5 with SDHD mutation–related HNPGLs. 68Ga-DOTATATE PET/CT (A) demonstrates lobulated finding in CB region on left side and additional lesion in GV region and in JT region on left side. JT findings are not visible on 18F-FDOPA PET/CT (B). 18F-FDG PET/CT (C) faintly demonstrates left CB and very faintly GV on left side. White arrow points to uptake in vocal cord. 18F-FDA PET/CT (D) is completely negative.

  • FIGURE 2.
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    FIGURE 2.

    Patient 19 with SDHD mutation–related HNPGLs. 68Ga-DOTATATE PET/CT (A) demonstrates big mass in GV region on right side and additional lesion in CB region on right (white arrow). Finding in CB region is not visible on 18F-FDOPA PET/CT (B). On 18F-FDG PET/CT, only GV lesion is seen faintly (C). 18F-FDA PET/CT (D) is negative.

  • FIGURE 3.
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    FIGURE 3.

    (A) Common sites of HNPGLs (black). (B) Localization of 7 lesions detected only on 68Ga-DOTATATE in our study (green). ACE = external carotid artery; ACI = internal carotid artery; CBP = carotid body paraganglioma; FC = carotid foramen; FJ = jugular foramen; JTP = JT paraganglioma; VP = vagale paraganglioma.

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    TABLE 1

    Lesions Identified in Head and Neck on 68Ga-DOTATATE, 18F-FDOPA, 18F-FDG, and 18F-FDA PET/CT and CT/MRI, Compared with Lesions Identified by Imaging Comparator

    Lesion68Ga-DOTATATE18F-FDOPA18F-FDG18F-FDACT/MRI
    JT12/1211/128/124/105/12
    CB10/1010/109/100/108/10
    GV8/88/86/83/77/8
    LN8/88/84/83/73/8
    Total38/3837/3827/3810/3423/38
    • LN = lymph node.

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    TABLE 2

    Metastatic Disease Identified in Patients and Sites Outside Head and Neck on 68Ga-DOTATATE, 18F-FDOPA, 18F-FDG, and 18F-FDA PET/CT and CT/MRI

    Metastatic disease68Ga-DOTATATE18F-FDOPA18F-FDG18F-FDACT/MRI
    Patients16/1613/1613/166/1415/16
    Abdomen5/53/53/52/42/5
    Bones12/128/1210/123/1110/12
    Liver2/20/21/20/22/2
    Lungs3/33/33/32/33/3
    Mediastinum8/84/84/81/76/8
    Total sites30/3018/3021/308/2723/30

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Journal of Nuclear Medicine: 57 (2)
Journal of Nuclear Medicine
Vol. 57, Issue 2
February 1, 2016
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68Ga-DOTATATE PET/CT in the Localization of Head and Neck Paragangliomas Compared with Other Functional Imaging Modalities and CT/MRI
Ingo Janssen, Clara C. Chen, David Taieb, Nicholas J. Patronas, Corina M. Millo, Karen T. Adams, Joan Nambuba, Peter Herscovitch, Samira M. Sadowski, Antonio T. Fojo, Inga Buchmann, Electron Kebebew, Karel Pacak
Journal of Nuclear Medicine Feb 2016, 57 (2) 186-191; DOI: 10.2967/jnumed.115.161018

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68Ga-DOTATATE PET/CT in the Localization of Head and Neck Paragangliomas Compared with Other Functional Imaging Modalities and CT/MRI
Ingo Janssen, Clara C. Chen, David Taieb, Nicholas J. Patronas, Corina M. Millo, Karen T. Adams, Joan Nambuba, Peter Herscovitch, Samira M. Sadowski, Antonio T. Fojo, Inga Buchmann, Electron Kebebew, Karel Pacak
Journal of Nuclear Medicine Feb 2016, 57 (2) 186-191; DOI: 10.2967/jnumed.115.161018
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Keywords

  • 68Ga-DOTATATE
  • 18F-FDOPA
  • head and neck paraganglioma
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