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Research ArticleClinical Investigations

The Impact of Optimal Respiratory Gating and Image Noise on Evaluation of Intratumor Heterogeneity on 18F-FDG PET Imaging of Lung Cancer

Willem Grootjans, Florent Tixier, Charlotte S. van der Vos, Dennis Vriens, Catherine C. Le Rest, Johan Bussink, Wim J.G. Oyen, Lioe-Fee de Geus-Oei, Dimitris Visvikis and Eric P. Visser
Journal of Nuclear Medicine November 2016, 57 (11) 1692-1698; DOI: https://doi.org/10.2967/jnumed.116.173112
Willem Grootjans
1Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Florent Tixier
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
3Department of Nuclear Medicine, DACTIM, University Hospital Poitiers, Poitiers, France
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Charlotte S. van der Vos
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Dennis Vriens
1Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
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Catherine C. Le Rest
3Department of Nuclear Medicine, DACTIM, University Hospital Poitiers, Poitiers, France
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Johan Bussink
4Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
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Wim J.G. Oyen
5Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom
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Lioe-Fee de Geus-Oei
6MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; and
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Dimitris Visvikis
7INSERM, UMR1101, LaTIM, University of Brest, Brest, France
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Eric P. Visser
2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Article Information

vol. 57 no. 11 1692-1698
DOI 
https://doi.org/10.2967/jnumed.116.173112
PubMed 
27283931

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 6, 2016
  • Accepted for publication May 10, 2016
  • Published online November 1, 2016.

Article Versions

  • previous version (June 9, 2016 - 10:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Willem Grootjans1,2,
  2. Florent Tixier2,3,
  3. Charlotte S. van der Vos2,
  4. Dennis Vriens1,
  5. Catherine C. Le Rest3,
  6. Johan Bussink4,
  7. Wim J.G. Oyen5,
  8. Lioe-Fee de Geus-Oei6,
  9. Dimitris Visvikis7 and
  10. Eric P. Visser2
  1. 1Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
  3. 3Department of Nuclear Medicine, DACTIM, University Hospital Poitiers, Poitiers, France
  4. 4Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
  5. 5Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom
  6. 6MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands; and
  7. 7INSERM, UMR1101, LaTIM, University of Brest, Brest, France
  1. For correspondence or reprints contact: Willem Grootjans, Department of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. E-mail: w.grootjans{at}lumc.nl
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Journal of Nuclear Medicine: 57 (11)
Journal of Nuclear Medicine
Vol. 57, Issue 11
November 1, 2016
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The Impact of Optimal Respiratory Gating and Image Noise on Evaluation of Intratumor Heterogeneity on 18F-FDG PET Imaging of Lung Cancer
Willem Grootjans, Florent Tixier, Charlotte S. van der Vos, Dennis Vriens, Catherine C. Le Rest, Johan Bussink, Wim J.G. Oyen, Lioe-Fee de Geus-Oei, Dimitris Visvikis, Eric P. Visser
Journal of Nuclear Medicine Nov 2016, 57 (11) 1692-1698; DOI: 10.2967/jnumed.116.173112

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The Impact of Optimal Respiratory Gating and Image Noise on Evaluation of Intratumor Heterogeneity on 18F-FDG PET Imaging of Lung Cancer
Willem Grootjans, Florent Tixier, Charlotte S. van der Vos, Dennis Vriens, Catherine C. Le Rest, Johan Bussink, Wim J.G. Oyen, Lioe-Fee de Geus-Oei, Dimitris Visvikis, Eric P. Visser
Journal of Nuclear Medicine Nov 2016, 57 (11) 1692-1698; DOI: 10.2967/jnumed.116.173112
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Keywords

  • 18F-FDG PET/CT
  • lung cancer
  • radiomics
  • Respiratory gating
  • total lesion glycolysis
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