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Research ArticleBasic Science Investigations

Impact of Recent Change in the National Institute of Standards and Technology Standard for 18F on the Relative Response of 68Ge-Based Mock Syringe Dose Calibrator Standards

Brian E. Zimmerman, Denis E. Bergeron and Jeffrey T. Cessna
Journal of Nuclear Medicine September 2015, 56 (9) 1453-1457; DOI: https://doi.org/10.2967/jnumed.115.159384
Brian E. Zimmerman
Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland
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Denis E. Bergeron
Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland
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Jeffrey T. Cessna
Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland
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Tables

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    TABLE 1

    Comparison of KVIC Values for Ampoule and Mock Syringe Geometries for 18F and 68Ge

    Nuclide, geometryKVIC (pA·MBq−1), present studyKVIC (pA·MBq−1), previous work
    68Ge, ampoule10.04(5)10.04(3)*
    68Ge, mock syringe10.00(5)10.00(5)
    18F, ampoule10.31(4)10.36(4)
    18F, mock syringe10.24(4)10.29(9)†
    • ↵* On the basis of the reported value of 10.12(3) pA·MBq−1 and corrected for differences in measurement geometry.

    • ↵† Adjusted unpublished value by −4% to reflect change in 18F.

    • Data are as measured in present study and as reported in Fitzgerald et al. (1) (for 18F) and Zimmerman and Cessna (3) (for 68Ge, denoted SSIC in that reference). Value of KVIC for 18F mock syringe was previously determined during experiments reported in Zimmerman and Cessna but was not included in the paper. Uncertainties are quoted as combined standard (k = 1) uncertainties. Details of uncertainty analysis are given in text (for present studies) or in appropriate reference.

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    TABLE 2

    Measured Dial Settings for 18F and 68Ge Mock Syringes in Several NIST-Maintained Activity Calibrators

    18F68Ge
    ChamberPrevious dial settingDial setting% activityPrevious dial settingDial setting% activity
    CRC-12472(2)460(4)0.6452(1)453(3)0.6
    CRC-15R—447(3)0.5442(1)436(3)0.5
    CRC-25PET—459(2)0.4—451(2)0.5
    CRC-35R—452(2)0.4444(1)447(5)0.9
    CRC-1.8 atm—496(2)0.4—488(3)0.5
    AL-500—10.1(2)2.0—10.1(1)0.5
    • Uncertainties (k = 1) are given in parentheses and are expressed as uncertainty in last digit of dial setting. % activity column gives uncertainty in measured activity value arising from uncertainty in dial setting. Values for previous dial settings for 18F and 68Ge are from Cessna et al. (11) and Zimmerman and Cessna (3), respectively.

    • View popup
    TABLE 3

    Average Ratios (Ravg) of Response of Commercial Activity Calibrators to 18F and 68Ge in Mock Syringe Geometry at Appropriate 68Ge Dial Setting (Table 2) for Each Specific Calibrator

    ChamberRavg
    CRC-121.015(8)
    CRC-15R1.022(7)
    CRC-25PET1.016(10)
    CRC-35R1.010(6)
    CRC-1.8 atm1.018(6)
    AL-5000.997(21)
    • Ratios were obtained by dividing activity readout from chamber for each 18F-FDG source by NIST-calibrated activity for that source. Uncertainties on response ratios were calculated from SD on average measured ratio from 3 sources and average uncertainties on 68Ge and 18F activities in mock syringes.

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Journal of Nuclear Medicine: 56 (9)
Journal of Nuclear Medicine
Vol. 56, Issue 9
September 1, 2015
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Impact of Recent Change in the National Institute of Standards and Technology Standard for 18F on the Relative Response of 68Ge-Based Mock Syringe Dose Calibrator Standards
Brian E. Zimmerman, Denis E. Bergeron, Jeffrey T. Cessna
Journal of Nuclear Medicine Sep 2015, 56 (9) 1453-1457; DOI: 10.2967/jnumed.115.159384

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Impact of Recent Change in the National Institute of Standards and Technology Standard for 18F on the Relative Response of 68Ge-Based Mock Syringe Dose Calibrator Standards
Brian E. Zimmerman, Denis E. Bergeron, Jeffrey T. Cessna
Journal of Nuclear Medicine Sep 2015, 56 (9) 1453-1457; DOI: 10.2967/jnumed.115.159384
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