PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments

Anneleen Blykers; Steve Schoonooghe; Catarina Xavier; Kevin D’hoe; Damya Laoui; Matthias D’Huyvetter; Ilse Vaneycken; Frederik Cleeren; Guy Bormans; Johannes Heemskerk; Geert Raes; Patrick De Baetselier; Tony Lahoutte; Nick Devoogdt; Jo A. Van Ginderachter; Vicky Caveliers

doi:10.2967/jnumed.115.156828

Research ArticleBasic Science Investigations

PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using ¹⁸F-Radiolabeled Camelid Single-Domain Antibody Fragments

Anneleen Blykers, Steve Schoonooghe, Catarina Xavier, Kevin D’hoe, Damya Laoui, Matthias D’Huyvetter, Ilse Vaneycken, Frederik Cleeren, Guy Bormans, Johannes Heemskerk, Geert Raes, Patrick De Baetselier, Tony Lahoutte, Nick Devoogdt, Jo A. Van Ginderachter and Vicky Caveliers

Journal of Nuclear Medicine August 2015, 56 (8) 1265-1271; DOI: https://doi.org/10.2967/jnumed.115.156828

Anneleen Blykers

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

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Steve Schoonooghe

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

3Laboratory of Myeloid Cell Immunology (MCI), VIB, Brussels, Belgium

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Catarina Xavier

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

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Kevin D’hoe

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

3Laboratory of Myeloid Cell Immunology (MCI), VIB, Brussels, Belgium

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Damya Laoui

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

3Laboratory of Myeloid Cell Immunology (MCI), VIB, Brussels, Belgium

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Matthias D’Huyvetter

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

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Ilse Vaneycken

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

4Department of Nuclear Medicine, UZ Brussel, Brussels, Belgium; and

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Frederik Cleeren

5Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium

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Guy Bormans

5Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium

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Johannes Heemskerk

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

4Department of Nuclear Medicine, UZ Brussel, Brussels, Belgium; and

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Geert Raes

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

3Laboratory of Myeloid Cell Immunology (MCI), VIB, Brussels, Belgium

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Patrick De Baetselier

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

3Laboratory of Myeloid Cell Immunology (MCI), VIB, Brussels, Belgium

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Tony Lahoutte

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

4Department of Nuclear Medicine, UZ Brussel, Brussels, Belgium; and

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Nick Devoogdt

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

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Jo A. Van Ginderachter

2Laboratory of Cellular and Molecular Immunology (CMIM), Vrije Universiteit Brussel, Brussels, Belgium

3Laboratory of Myeloid Cell Immunology (MCI), VIB, Brussels, Belgium

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Vicky Caveliers

1In Vivo Cellular and Molecular Imaging laboratory (ICMI), Vrije Universiteit Brussel, Brussels, Belgium

4Department of Nuclear Medicine, UZ Brussel, Brussels, Belgium; and

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PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using ¹⁸F-Radiolabeled Camelid Single-Domain Antibody Fragments

Journal of Nuclear Medicine Aug 2015, 56 (8) 1265-1271; DOI: 10.2967/jnumed.115.156828

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PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using ¹⁸F-Radiolabeled Camelid Single-Domain Antibody Fragments

Journal of Nuclear Medicine Aug 2015, 56 (8) 1265-1271; DOI: 10.2967/jnumed.115.156828

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Keywords

Macrophage Mannose Receptor (MMR)
camelid single-domain antibody fragment (sdAb)
18F
PET
tumor microenvironment

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PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using ¹⁸F-Radiolabeled Camelid Single-Domain Antibody Fragments

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