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Research ArticleClinical Investigations

18F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer

Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper and Steve Y. Cho
Journal of Nuclear Medicine July 2015, 56 (7) 1003-1010; DOI: https://doi.org/10.2967/jnumed.115.154336
Steven P. Rowe
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Kenneth L. Gage
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Sheila F. Faraj
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Katarzyna J. Macura
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Toby C. Cornish
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Nilda Gonzalez-Roibon
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Gunes Guner
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Enrico Munari
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Alan W. Partin
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
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Christian P. Pavlovich
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
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Misop Han
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
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H. Ballentine Carter
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
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Trinity J. Bivalacqua
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
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Amanda Blackford
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Daniel Holt
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Robert F. Dannals
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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George J. Netto
2Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland
3The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland; and
4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Martin A. Lodge
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Ronnie C. Mease
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Martin G. Pomper
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Steve Y. Cho
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland
4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland
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Journal of Nuclear Medicine: 56 (7)
Journal of Nuclear Medicine
Vol. 56, Issue 7
July 1, 2015
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18F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper, Steve Y. Cho
Journal of Nuclear Medicine Jul 2015, 56 (7) 1003-1010; DOI: 10.2967/jnumed.115.154336

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18F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper, Steve Y. Cho
Journal of Nuclear Medicine Jul 2015, 56 (7) 1003-1010; DOI: 10.2967/jnumed.115.154336
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  • Diagnostic Efficacy of Various Imaging Modalities Across Different Stages of Prostate Cancer: A Network Meta-Analysis of Diagnostic Studies
  • Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL PET/CT
  • The History of Prostate-Specific Membrane Antigen as a Theranostic Target in Prostate Cancer: The Cornerstone Role of the Prostate Cancer Foundation
  • Radiolabeling of PSMA-617 with 89Zr: A Novel Use of DMSO for Radiochemical Yield Enhancement and Preliminary Small-Animal PET Results
  • 18F-DCFPyL PET/CT Imaging in Patients with Biochemically Recurrent Prostate Cancer After Primary Local Therapy
  • Prostate Specific Membrane Antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to brain
  • Radiation Dosimetry and Biodistribution of 18F-PSMA-11 for PET Imaging of Prostate Cancer
  • One-Step 18F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging
  • Imaging of Nonprostate Cancers Using PSMA-Targeted Radiotracers: Rationale, Current State of the Field, and a Call to Arms
  • Prospective Evaluation of 68Ga-RM2 PET/MRI in Patients with Biochemical Recurrence of Prostate Cancer and Negative Findings on Conventional Imaging
  • Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging
  • Why Targeting PSMA Is a Game Changer in the Management of Prostate Cancer
  • Will GRPR Compete with PSMA as a Target in Prostate Cancer?
  • Intraindividual Comparison of 18F-PSMA-1007 PET/CT, Multiparametric MRI, and Radical Prostatectomy Specimens in Patients with Primary Prostate Cancer: A Retrospective, Proof-of-Concept Study
  • PSMA Ligands for PET Imaging of Prostate Cancer
  • Glu-Ureido-Based Inhibitors of Prostate-Specific Membrane Antigen: Lessons Learned During the Development of a Novel Class of Low-Molecular-Weight Theranostic Radiotracers
  • Phase 2 Study of 99mTc-Trofolastat SPECT/CT to Identify and Localize Prostate Cancer in Intermediate- and High-Risk Patients Undergoing Radical Prostatectomy and Extended Pelvic LN Dissection
  • Prostate-Specific Membrane Antigen Ligands for Imaging and Therapy
  • Semiquantitative Parameters in PSMA-Targeted PET Imaging with 18F-DCFPyL: Variability in Normal-Organ Uptake
  • Preclinical Evaluation and First Patient Application of 99mTc-PSMA-I&S for SPECT Imaging and Radioguided Surgery in Prostate Cancer
  • 68Ga-PSMA PET/CT Detects the Location and Extent of Primary Prostate Cancer
  • What Medical, Urologic, and Radiation Oncologists Want from Molecular Imaging of Prostate Cancer
  • Evaluation of Prostate Cancer with PET/MRI
  • Prostate-Specific Membrane Antigen-Targeted Radiohalogenated PET and Therapeutic Agents for Prostate Cancer
  • Response and Tolerability of a Single Dose of 177Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer: A Multicenter Retrospective Analysis
  • Correlation of Intraprostatic Tumor Extent with 68Ga-PSMA Distribution in Patients with Prostate Cancer
  • Comparison of Prostate-Specific Membrane Antigen-Based 18F-DCFBC PET/CT to Conventional Imaging Modalities for Detection of Hormone-Naive and Castration-Resistant Metastatic Prostate Cancer
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Keywords

  • primary prostate cancer
  • prostate specific membrane antigen (PSMA)
  • PET/CT
  • MRI
  • prostatectomy
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