18F-Florbetapir PET in Patients with Frontotemporal Dementia and Alzheimer Disease

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FIGURE 1.
Whole neocortical ¹⁸F-florbetapir SUVRs relative to cerebellar gray matter in patients with AD and FTD and healthy controls. Points represent individual subject values and bars median values (Kruskal–Wallis test followed by pairwise post hoc test corrected for multiple comparisons). Subjects in whom most visual interpretation was discordant from their clinical diagnosis are indicated as open symbols.
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FIGURE 2.
Gray-scale ¹⁸F-florbetapir scans as used for visual interpretation. (A) Patient 4 in Supplemental Table 1, patient 12 (B), patient 18 (C), patient 11 (D).
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FIGURE 3.
Transaxial coregistered images from FTD subject with discordant visual interpretations (subject 15 in Supplemental Table 1) of gray-scale ¹⁸F-florbetapir PET (A), T1-weighted MR brain (B), and color-scale ¹⁸F-florbetapir PET fused to MR brain (C). Arrows indicate apparent areas of high ¹⁸F-florbetapir uptake as a result of loss of contrast due to low white matter uptake or cortical atrophy leading to inconsistent visual interpretations.

TABLE 1

Demographic Information on Subjects Recruited to Study

Characteristic	Healthy controls (n = 10)	FTD (n = 8)	AD (n = 10)
Age (y)	62.5 ± 5.1	62.5 ± 9.6	62.6 ± 4.5
Sex
Male	4	8	7
Female	6		3
Disease duration (y)	—	4.6 ± 1.8	4.9 ± 1.7
MMSE	30	26.5 (0–30)	18.0 (10–24)
Total Clinical Dementia Rating score	0	1.0 (0.5–2.0)	1.0 (0.5–2.0)
APOE ε4 carriers (0/1/2 gene copies)	—	4/3/1	4/3/3

Data are mean ± SD for age and disease duration and median (with range in parentheses) in all other cases.

TABLE 2

Regional ¹⁸F-Florbetapir Uptake Ratios Normalized to Gray Matter Cerebellar Uptake for Subjects with FTD and AD and Healthy Controls

↵* P < 0.05 vs. AD (Kruskal–Wallis test followed by post hoc pairwise tests adjusted for multiple comparisons).
↵† P < 0.01 vs. AD (Kruskal–Wallis test followed by post hoc pairwise tests adjusted for multiple comparisons).
Data are presented as median, with interquartile range in parentheses, in all cases.