Article Figures & Data
Figures
- FIGURE 1.
Distributions of Gleason scores and PSA cutoff values. doubt = doubtful; neg = negative; pos = positive.
- FIGURE 2.
ROC analysis. Values of 1.5 ng/mL for serum PSA and 7 for Gleason score (GS) were defined as best cutoff values for predicting positive 18F-choline PET/CT scan. AUC = area under the curve.
Tables
Characteristic Value Age (y)* 69.68 ± 7.67 Center CRO 626 (62.6) Medical Center Ljubljana 79 (7.9) IOV 227 (22.7) University of Pisa 68 (6.8) GS ≤6 257 (25.7) 7 347 (34.7) >7 396 (39.6) Actual GS 2 2 (0.2) 3 4 (0.4) 4 9 (0.9) 5 43 (4.3) 6 199 (19.9) 7 347 (34.7) 8 223 (22.3) 9 155 (15.5) 10 18 (1.8) Primary treatment Surgery alone 353 (35.3) Surgery and adjuvant EBRT (with or without HT) 167 (16.7) EBRT (with or without HT) 152 (15.2) HT alone 121 (12.1) NA 207 (20.7) PSA level, in ng/mL† 3.30 (1.15–11.0) ↵* Reported as mean ± SD.
↵† Reported as median (IQR).
CRO = IRCCS National Cancer Institute; IOV = Veneto Institute of Oncology; EBRT = external beam radiotherapy; HT = hormone therapy; NA = not available.
Values are reported as number of patients followed by percentage in parentheses unless otherwise indicated.
Characteristic Negative PET/CT Positive PET/CT Doubtful PET/CT P n 300 645 55 PSA level, in ng/mL* 1.20 (0.58–2.35) 6.65 (2.56–17.47) 1.8 (0.85–3.9) 0.073† PSA range <1 ng/mL 127 (42.3) 66 (10.2) 18 (32.7) <0.001‡ ≥1 but <2 ng/mL 74 (24.7) 66 (10.2) 13 (23.6) ≥2 ng/mL 99 (33) 513 (79.5) 24 (43.6) GS ≤6 113 (37.7) 127 (19.7) 17 (30.9) <0.001‡ 7 120 (40) 206 (31.9) 21 (38.2) >7 67 (22.3) 312 (48.4) 17 (30.9) Type of therapy RP alone 161 (53.7) 162 (25.1) 30 (54.5) <0.001‡ RP and adjuvant EBRT (with or without HT) 50 (16.7) 107 (16.6) 10 (18.2) EBRT (with or without HT) 35 (11.7) 113 (17.5) 4 (7.3) HT alone 10 (3.3) 109 (16.9) 2 (3.6) NA 44 (14.7) 154 (23.9) 9 (16.4) Univariable Multivariable Parameter OR 95% CI P OR 95% CI P Age 1.035 1.016–1.054 <0.001 1.025 1.003–1.048 <0.05 GS ≤ 6 GS = 7 0.241 0.167–0.348 <0.001 0.226 0.145–0.3351 <0.001 GS > 7 0.369 0.261–0.521 <0.001 0.330 0.216–0.503 <0.001 Surgery (yes vs. no) 1.463 0.885–2.416 0.138 EBRT (yes vs. no) 0.466 0.303–0.717 <0.05 2.221 0.342–14.41 0.403 HT (yes vs. no) 0.357 0.225–0.567 <0.001 1.00 Ongoing HT (yes vs. no) 0.490 0.313–0.978 <0.005 1.00 Chemotherapy (yes vs. no) 0.488 0.321–0.742 <0.05 0.203 0.074–0.560 <0.05 PSA of <1 PSA ≥1 but <2 0.100 0.069–0.145 <0.001 0.092 0.060–0.141 <0.001 PSA of ≥2 0.172 0.116–0.256 <0.001 0.206 0.134–0.316 <0.001 OR = odds ratio; CI = confidence interval; EBRT = external-beam radiotherapy; HT = hormonal therapy.
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