Article Figures & Data
Figures
- FIGURE 1.
Illustration of primary lung tumors with Hvisu values of 1, 2, and 3 (A, B, and C, respectively). Green contours are FLAB delineations, and examples of features are provided (values normalized between 0 and 1).
- FIGURE 2.
Illustration of distributions of homogeneity (A) and ZP (B) according to 3 levels of Hvisu.
- FIGURE 3.
Examples of survival curves for OS (n = 102) according to stage (A), SUVmax (B), Hvisu (C), and ZP (D).
- FIGURE 4.
Survival curves for OS (n = 102) with stratification obtained according to combination of MATV, entropy, and ZP.
- FIGURE 5.
Differentiation of 4 different OS groups using MATV alone (A) or MATV (B) and substratification with entropy.
- FIGURE 6.
Examples of survival curves for RFS (n = 48) according to Hvisu (A) and dissimilarity (B).
Tables
Characteristic n Sex Male 79 (78) Female 23 (22) Age (y) Range 48–84 Median ± SD 64 ± 8.9 Smoker No 16 (16) Yes 86 (84) Treatment Surgery only 18 (18) Chemotherapy only 12 (12) Radiotherapy only 0 (0) Surgery + chemotherapy 20 (19) Surgery + radiotherapy 1 (1) Chemotherapy + radiotherapy 42 (41) Chemotherapy + radiotherapy + surgery 9 (9) TNM stage T1 13 (13) T2 55 (53) T3 21 (21) T4 13 (13) N0 32 (31) N1 23 (23) N2 29 (28) N3 18 (18) M0 102 (100) M1 0 (0) Clinical stage I 18 (18) II 30 (29) III 54 (53) IV 0 (0) Histology Adenocarcinoma 53 (52) Squamous cell carcinoma 49 (48) Data in parentheses are percentages.
Parameter Univariate P Multivariate P Clinical Surgery 0.006 — Age 0.03 — Sex 0.02 — Smoker 0.9 — Histology 0.3 — Stage 0.001 <0.03 SUV and volumetric 0.009 — SUVmax SUVmean 0.008 — MATV <0.0001 0.0001 TLG 0.001 0.006 Global heterogeneity SUVCOV 0.4 — CHAUC 0.9 — Visual heterogeneity Hvisu ≥ 2 1 — Hvisu = 3 1 — Local heterogeneity (TF) Entropy <0.0001 0.0001 Homogeneity 0.008 0.03 Dissimilarity 0.007 0.01 Regional heterogeneity (TF) HIE 0.9 — SZV <0.0001 0.0002 ZP <0.0001 0.0001 Parameter Univariate P Clinical Age 0.9 Sex 0.2 Smoker 0.1 Histology 0.7 Stage 0.1 SUV and volumetric SUVmax 1 SUVmean 0.6 MATV 0.001 TLG 0.03 Visual heterogeneity Hvisu ≥ 2 1 Hvisu = 3 0.3 Global heterogeneity SUVcov 1 CHAUC 0.8 Local heterogeneity (TF) Entropy 0.004 Homogeneity 0.005 Dissimilarity 0.001 Regional heterogeneity (TF) HIE 0.7 SZV 0.004 ZP 0.004
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