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Research ArticleBasic Science Investigations

An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of 11C-LY2459989

Ming-Qiang Zheng, Su Jin Kim, Daniel Holden, Shu-fei Lin, Anne Need, Karen Rash, Vanessa Barth, Charles Mitch, Antonio Navarro, Michael Kapinos, Kathleen Maloney, Jim Ropchan, Richard E. Carson and Yiyun Huang
Journal of Nuclear Medicine July 2014, 55 (7) 1185-1191; DOI: https://doi.org/10.2967/jnumed.114.138701
Ming-Qiang Zheng
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Su Jin Kim
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Daniel Holden
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Shu-fei Lin
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Anne Need
2Eli Lilly & Company, Indianapolis, Indiana
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Karen Rash
2Eli Lilly & Company, Indianapolis, Indiana
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Vanessa Barth
2Eli Lilly & Company, Indianapolis, Indiana
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Charles Mitch
2Eli Lilly & Company, Indianapolis, Indiana
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Antonio Navarro
2Eli Lilly & Company, Indianapolis, Indiana
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Michael Kapinos
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Kathleen Maloney
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Jim Ropchan
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Richard E. Carson
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Yiyun Huang
1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
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Article Information

vol. 55 no. 7 1185-1191
DOI 
https://doi.org/10.2967/jnumed.114.138701
PubMed 
24854795

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 8, 2014
  • Accepted for publication March 25, 2014
  • Published online July 1, 2014.

Article Versions

  • previous version (May 22, 2014 - 05:37).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Ming-Qiang Zheng1,
  2. Su Jin Kim1,
  3. Daniel Holden1,
  4. Shu-fei Lin1,
  5. Anne Need2,
  6. Karen Rash2,
  7. Vanessa Barth2,
  8. Charles Mitch2,
  9. Antonio Navarro2,
  10. Michael Kapinos1,
  11. Kathleen Maloney1,
  12. Jim Ropchan1,
  13. Richard E. Carson1 and
  14. Yiyun Huang1
  1. 1PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut; and
  2. 2Eli Lilly & Company, Indianapolis, Indiana
  1. For correspondence or reprints contact: Yiyun (Henry) Huang, PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, P.O. Box 208048, 801 Howard Ave., New Haven, CT 06520-8048. E-mail: henry.huang{at}yale.edu
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Journal of Nuclear Medicine: 55 (7)
Journal of Nuclear Medicine
Vol. 55, Issue 7
July 1, 2014
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An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of 11C-LY2459989
Ming-Qiang Zheng, Su Jin Kim, Daniel Holden, Shu-fei Lin, Anne Need, Karen Rash, Vanessa Barth, Charles Mitch, Antonio Navarro, Michael Kapinos, Kathleen Maloney, Jim Ropchan, Richard E. Carson, Yiyun Huang
Journal of Nuclear Medicine Jul 2014, 55 (7) 1185-1191; DOI: 10.2967/jnumed.114.138701

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An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of 11C-LY2459989
Ming-Qiang Zheng, Su Jin Kim, Daniel Holden, Shu-fei Lin, Anne Need, Karen Rash, Vanessa Barth, Charles Mitch, Antonio Navarro, Michael Kapinos, Kathleen Maloney, Jim Ropchan, Richard E. Carson, Yiyun Huang
Journal of Nuclear Medicine Jul 2014, 55 (7) 1185-1191; DOI: 10.2967/jnumed.114.138701
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  • Development and In Vivo Evaluation of a {kappa}-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics
  • Novel 18F-Labeled {kappa}-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates
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Keywords

  • Kappa opioid receptor
  • antagonist
  • PET
  • radioligand
  • synthesis and evaluation
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