In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18F-PBR111 PET

Alessandro Colasanti; Qi Guo; Nils Muhlert; Paolo Giannetti; Mayca Onega; Rexford D. Newbould; Olga Ciccarelli; Stuart Rison; Charlotte Thomas; Richard Nicholas; Paolo A. Muraro; Omar Malik; David R. Owen; Paola Piccini; Roger N. Gunn; Eugenii A. Rabiner; Paul M. Matthews

doi:10.2967/jnumed.113.135129

Research ArticleClinical Investigations

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with ¹⁸F-PBR111 PET

Alessandro Colasanti, Qi Guo, Nils Muhlert, Paolo Giannetti, Mayca Onega, Rexford D. Newbould, Olga Ciccarelli, Stuart Rison, Charlotte Thomas, Richard Nicholas, Paolo A. Muraro, Omar Malik, David R. Owen, Paola Piccini, Roger N. Gunn, Eugenii A. Rabiner and Paul M. Matthews

Journal of Nuclear Medicine July 2014, 55 (7) 1112-1118; DOI: https://doi.org/10.2967/jnumed.113.135129

Alessandro Colasanti

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

2Imanova Centre for Imaging Sciences, London, United Kingdom

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Qi Guo

2Imanova Centre for Imaging Sciences, London, United Kingdom

3Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, United Kingdom

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Nils Muhlert

4UCL Institute of Neurology, London, United Kingdom

5School of Psychology and Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom

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Paolo Giannetti

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

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Mayca Onega

2Imanova Centre for Imaging Sciences, London, United Kingdom

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Rexford D. Newbould

2Imanova Centre for Imaging Sciences, London, United Kingdom

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Olga Ciccarelli

4UCL Institute of Neurology, London, United Kingdom

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Stuart Rison

6Imperial College Healthcare NHS Trust, London, United Kingdom; and

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Charlotte Thomas

6Imperial College Healthcare NHS Trust, London, United Kingdom; and

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Richard Nicholas

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

6Imperial College Healthcare NHS Trust, London, United Kingdom; and

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Paolo A. Muraro

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

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Omar Malik

6Imperial College Healthcare NHS Trust, London, United Kingdom; and

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David R. Owen

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

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Paola Piccini

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

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Roger N. Gunn

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

2Imanova Centre for Imaging Sciences, London, United Kingdom

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Eugenii A. Rabiner

2Imanova Centre for Imaging Sciences, London, United Kingdom

3Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, United Kingdom

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Paul M. Matthews

1Division of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

7Neurosciences, GlaxoSmithKline, Brentford, United Kingdom

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Journal of Nuclear Medicine

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July 1, 2014

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In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with ¹⁸F-PBR111 PET

Journal of Nuclear Medicine Jul 2014, 55 (7) 1112-1118; DOI: 10.2967/jnumed.113.135129

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In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with ¹⁸F-PBR111 PET

Journal of Nuclear Medicine Jul 2014, 55 (7) 1112-1118; DOI: 10.2967/jnumed.113.135129

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Keywords

multiple sclerosis
TSPO
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lesion
PET
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