Article Figures & Data
Figures
- FIGURE 1.
Voxel-based group comparison reveals statistically significant differences in measured regional activity in AC (left) and NAC (right) data between PET/MR and PET/CT. For display, green was used for relatively higher measured PET signal in PET/MR than PET/CT (extent threshold in AC, T = 2.50, P < 0.05, false discovery rate–corrected; in NAC, T = 2.05, P < 0.05, false discovery rate–corrected), and red represented relatively higher measured PET signal in PET/CT (extent threshold in AC, T = 2.12, P < 0.05, false discovery rate–corrected; in NAC, T = 2.77, P < 0.05, false discovery rate–corrected).
- FIGURE 2.
Percentage differences of values in different anatomic regions by ROI-based analysis. Error bars indicate SD.
- FIGURE 3.
Percentage differences of values in different anatomic regions by ROI-based analysis in data corrected for global differences. Error bars indicate SD. n.s. = no significant difference between PET/MR and PET/CT.
- FIGURE 4.
Patient 1 (PET/CT first): 3DSSPs generated by Neurostat after anatomic stereotactic normalization of same patient examined with PET/CT (A) and PET/MR (B). 3DSSPs of individual patient’s 18F-FDG PET data (upper) and pixelwise comparison of individual patient’s PET data to age-matched reference database, resulting in z score images (high z score = significantly reduced glucose metabolism; reference region: global mean) (lower). Compared with PET/CT, lower relative metabolic rate can be observed in frontoparietal portions of neocortex in PET/MR data on 3DSSP images (red arrows). On z score images, relatively stronger deviations from control are detected (green arrows) for PET/MR data.
Tables
Patient no. Sex Age (y) Examination sequence Time interval (min) between PET/MR and PET/CT 1 M 69 PET/CT first 34 2 F 39 PET/CT first 36 3 M 71 PET/CT first 46 4 F 52 PET/CT first 35 5 M 60 PET/CT first 33 6 M 76 PET/CT first 70 7 F 75 PET/CT first 33 8 F 25 PET/CT first 48 9 F 61 PET/MR first 40 10 F 53 PET/MR first 40 11 F 45 PET/MR first 37 12 M 45 PET/MR first 29 13 F 46 PET/MR first 41 14 F 61 PET/CT first 29 15 F 70 PET/CT first 26 16 M 64 PET/CT first 37 17 F 74 PET/CT first 37 18 M 73 PET/MR first 25 19 F 79 PET/MR first 50 20 M 64 PET/MR first 42 21 F 70 PET/MR first 22 22 F 45 PET/MR first 22 23 F 66 PET/MR first 34 24 F 68 PET/MR first 44 25 F 57 PET/MR first 32 26 F 55 PET/MR first 40 27 F 64 PET/CT first 44 28 M 67 PET/CT first 30 29 F 72 PET/CT first 40 30 M 60 PET/CT first 25 Characteristic PET/CT first PET/MR first P n 16 14 Not significant Patient median age (y) 65.5 59 Not significant Time between PET/MR and PET/CT 37.69 ± 10.85 35.57 ± 8.55 Not significant Male 7 3 Not significant Female 9 11 Not significant Data type Basal ganglia Cerebellum Frontal Occipital Parietal Pons Temporal Central AC data PET/MR AC 1.04 ± 0.06 1.04 ± 0.05 0.98 ± 0.03 1.08 ± 0.05 1.03 ± 0.05 0.83 ± 0.05 0.95 ± 0.04 1.05 ± 0.04 PET/CT AC 0.96 ± 0.06 1.01 ± 0.05 1.02 ± 0.04 1.09 ± 0.09 1.08 ± 0.06 0.78 ± 0.08 0.95 ± 0.05 1.12 ± 0.04 Difference between PET/CT and PET/MR −0.08 −0.03 0.04 0.01 0.05 −0.06 0.00 0.07 % Difference PET/MR (PET/CT = 100%) 8.66 3.01 −4.08 −0.86 −4.49 7.48 −0.11 −6.33 P (PET/CT vs. PET/MR) P < 0.001 P < 0.001 P < 0.001 NS P < 0.001 P < 0.001 NS P < 0.001 NAC data PET/MR NAC 0.84 ± 0.09 0.97 ± 0.05 1.12 ± 0.05 1.16 ± 0.08 1.15 ± 0.07 0.62 ± 0.07 0.98 ± 0.04 1.16 ± 0.06 PET/CT NAC 0.78 ± 0.11 0.96 ± 0.05 1.12 ± 0.05 1.19 ± 0.09 1.18 ± 0.07 0.57 ± 0.07 0.99 ± 0.05 1.20 ± 0.07 Difference between PET/CT and PET/MR −0.06 0.00 0.00 0.04 0.03 −0.05 0.01 0.03 % Difference PET/MR (PET/CT = 100%) 7.41 0.13 0.36 −3.34 −2.48 8.13 −0.85 −2.68 P (PET/CT vs. PET/MR) P < 0.001 NS NS P < 0.001 P < 0.001 P < 0.001 NS P < 0.001 Mean uptake values obtained by ROI analysis, normalized to individual global mean.
NS = no significant difference.
Supplemental Data
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