Three-Dimensional Histologic Validation of High-Resolution SPECT of Antibody Distributions Within Xenografts

Woutjan Branderhorst; Erwin L.A. Blezer; Mischa Houtkamp; Ruud M. Ramakers; Jeroen H. van den Brakel; Henry Witteveen; Frans van der Have; Hugo A. Gratama van Andel; Brendan Vastenhouw; Chao Wu; Marijke Stigter-van Walsum; Guus A.M.S. van Dongen; Max A. Viergever; Wim K. Bleeker; Freek J. Beekman

doi:10.2967/jnumed.113.125401

Research ArticleBasic Science Investigations

Three-Dimensional Histologic Validation of High-Resolution SPECT of Antibody Distributions Within Xenografts

Woutjan Branderhorst, Erwin L.A. Blezer, Mischa Houtkamp, Ruud M. Ramakers, Jeroen H. van den Brakel, Henry Witteveen, Frans van der Have, Hugo A. Gratama van Andel, Brendan Vastenhouw, Chao Wu, Marijke Stigter-van Walsum, Guus A.M.S. van Dongen, Max A. Viergever, Wim K. Bleeker and Freek J. Beekman

Journal of Nuclear Medicine May 2014, 55 (5) 830-837; DOI: https://doi.org/10.2967/jnumed.113.125401

Woutjan Branderhorst

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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Erwin L.A. Blezer

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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Mischa Houtkamp

4Genmab B.V., Utrecht, The Netherlands

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Ruud M. Ramakers

2Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

5Section Radiation, Detection, and Medical Imaging, Applied Sciences, Delft University of Technology, Delft, The Netherlands

6MILabs B.V., Utrecht, The Netherlands; and

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Jeroen H. van den Brakel

4Genmab B.V., Utrecht, The Netherlands

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Henry Witteveen

4Genmab B.V., Utrecht, The Netherlands

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Frans van der Have

5Section Radiation, Detection, and Medical Imaging, Applied Sciences, Delft University of Technology, Delft, The Netherlands

6MILabs B.V., Utrecht, The Netherlands; and

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Hugo A. Gratama van Andel

6MILabs B.V., Utrecht, The Netherlands; and

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Brendan Vastenhouw

5Section Radiation, Detection, and Medical Imaging, Applied Sciences, Delft University of Technology, Delft, The Netherlands

6MILabs B.V., Utrecht, The Netherlands; and

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Chao Wu

5Section Radiation, Detection, and Medical Imaging, Applied Sciences, Delft University of Technology, Delft, The Netherlands

6MILabs B.V., Utrecht, The Netherlands; and

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Marijke Stigter-van Walsum

7Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands

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Guus A.M.S. van Dongen

7Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands

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Max A. Viergever

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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Wim K. Bleeker

4Genmab B.V., Utrecht, The Netherlands

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Freek J. Beekman

5Section Radiation, Detection, and Medical Imaging, Applied Sciences, Delft University of Technology, Delft, The Netherlands

6MILabs B.V., Utrecht, The Netherlands; and

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May 1, 2014

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Three-Dimensional Histologic Validation of High-Resolution SPECT of Antibody Distributions Within Xenografts

Journal of Nuclear Medicine May 2014, 55 (5) 830-837; DOI: 10.2967/jnumed.113.125401

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Three-Dimensional Histologic Validation of High-Resolution SPECT of Antibody Distributions Within Xenografts

Journal of Nuclear Medicine May 2014, 55 (5) 830-837; DOI: 10.2967/jnumed.113.125401

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Keywords

micro-SPECT
histology
antibody
zalutumumab
EGFR

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