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Research ArticleBasic Science Investigations

Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis

Fang Zheng, Stéphanie Put, Luc Bouwens, Tony Lahoutte, Patrick Matthys, Serge Muyldermans, Patrick De Baetselier, Nick Devoogdt, Geert Raes and Steve Schoonooghe
Journal of Nuclear Medicine May 2014, 55 (5) 824-829; DOI: https://doi.org/10.2967/jnumed.113.130617
Fang Zheng
1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
2VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium
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Stéphanie Put
3Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
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Luc Bouwens
4Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel, Brussels, Belgium
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Tony Lahoutte
5In Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium
6Department of Nuclear Medicine, UZ Brussel, Vrije Universtiteit Brussel, Brussels, Belgium; and
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Patrick Matthys
3Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
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Serge Muyldermans
1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
7VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
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Patrick De Baetselier
1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
2VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium
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Nick Devoogdt
5In Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium
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Geert Raes
1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
2VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium
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Steve Schoonooghe
1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
2VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium
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Article Information

vol. 55 no. 5 824-829
DOI 
https://doi.org/10.2967/jnumed.113.130617
PubMed 
24686780

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication August 7, 2013
  • Accepted for publication January 1, 2014
  • Published online May 2, 2014.

Article Versions

  • previous version (March 31, 2014 - 08:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Fang Zheng1,2,
  2. Stéphanie Put3,
  3. Luc Bouwens4,
  4. Tony Lahoutte5,6,
  5. Patrick Matthys3,
  6. Serge Muyldermans1,7,
  7. Patrick De Baetselier1,2,
  8. Nick Devoogdt*,5,
  9. Geert Raes*,1,2 and
  10. Steve Schoonooghe*,1,2
  1. 1Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium
  2. 2VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium
  3. 3Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
  4. 4Cell Differentiation Unit, Diabetes Research Centre, Vrije Universiteit Brussel, Brussels, Belgium
  5. 5In Vivo Cellular and Molecular Imaging Center, Vrije Universiteit Brussel, Brussels, Belgium
  6. 6Department of Nuclear Medicine, UZ Brussel, Vrije Universtiteit Brussel, Brussels, Belgium; and
  7. 7VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
  1. For correspondence or reprints contact: Steve Schoonooghe, Laboratory of Cellular and Molecular Immunology, VIB Laboratory of Myeloid Cell Immunology, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. E-mail: sschoono{at}vub.ac.be
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Journal of Nuclear Medicine: 55 (5)
Journal of Nuclear Medicine
Vol. 55, Issue 5
May 1, 2014
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Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis
Fang Zheng, Stéphanie Put, Luc Bouwens, Tony Lahoutte, Patrick Matthys, Serge Muyldermans, Patrick De Baetselier, Nick Devoogdt, Geert Raes, Steve Schoonooghe
Journal of Nuclear Medicine May 2014, 55 (5) 824-829; DOI: 10.2967/jnumed.113.130617

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Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis
Fang Zheng, Stéphanie Put, Luc Bouwens, Tony Lahoutte, Patrick Matthys, Serge Muyldermans, Patrick De Baetselier, Nick Devoogdt, Geert Raes, Steve Schoonooghe
Journal of Nuclear Medicine May 2014, 55 (5) 824-829; DOI: 10.2967/jnumed.113.130617
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Keywords

  • complement receptor of the Ig superfamily (CRIg, VSIG4, or Z39Ig)
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  • SPECT/μCT
  • Nanobody
  • macrophage
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