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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

Quantitative ImmunoPET of Prostate Cancer Xenografts with 89Zr- and 124I-Labeled Anti-PSCA A11 Minibody

Scott M. Knowles, Kirstin A. Zettlitz, Richard Tavaré, Matthew M. Rochefort, Felix B. Salazar, David B. Stout, Paul J. Yazaki, Robert E. Reiter and Anna M. Wu
Journal of Nuclear Medicine March 2014, 55 (3) 452-459; DOI: https://doi.org/10.2967/jnumed.113.120873
Scott M. Knowles
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Kirstin A. Zettlitz
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Richard Tavaré
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Matthew M. Rochefort
2Department of Surgery, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Felix B. Salazar
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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David B. Stout
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Paul J. Yazaki
3Department of Immunology, Beckman Research Institute of the City of Hope, Duarte, California; and
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Robert E. Reiter
4Department of Urology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Anna M. Wu
1Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California–Los Angeles, Los Angeles, California
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Journal of Nuclear Medicine: 55 (3)
Journal of Nuclear Medicine
Vol. 55, Issue 3
March 1, 2014
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Quantitative ImmunoPET of Prostate Cancer Xenografts with 89Zr- and 124I-Labeled Anti-PSCA A11 Minibody
Scott M. Knowles, Kirstin A. Zettlitz, Richard Tavaré, Matthew M. Rochefort, Felix B. Salazar, David B. Stout, Paul J. Yazaki, Robert E. Reiter, Anna M. Wu
Journal of Nuclear Medicine Mar 2014, 55 (3) 452-459; DOI: 10.2967/jnumed.113.120873

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Quantitative ImmunoPET of Prostate Cancer Xenografts with 89Zr- and 124I-Labeled Anti-PSCA A11 Minibody
Scott M. Knowles, Kirstin A. Zettlitz, Richard Tavaré, Matthew M. Rochefort, Felix B. Salazar, David B. Stout, Paul J. Yazaki, Robert E. Reiter, Anna M. Wu
Journal of Nuclear Medicine Mar 2014, 55 (3) 452-459; DOI: 10.2967/jnumed.113.120873
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Cited By...

  • Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET
  • Near-Infrared Dye-Labeled Anti-Prostate Stem Cell Antigen Minibody Enables Real-Time Fluorescence Imaging and Targeted Surgery in Translational Mouse Models
  • Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody
  • ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo
  • Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells
  • Fluorescent Image-Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time
  • An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
  • Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies
  • 89Zr-Labeled Versus 124I-Labeled {alpha}HER2 Fab with Optimized Plasma Half-Life for High-Contrast Tumor Imaging In Vivo
  • Applications of ImmunoPET: Using 124I-Anti-PSCA A11 Minibody for Imaging Disease Progression and Response to Therapy in Mouse Xenograft Models of Prostate Cancer
  • Anti-MET ImmunoPET for Non-Small Cell Lung Cancer Using Novel Fully Human Antibody Fragments
  • Improved Modeling of In Vivo Kinetics of Slowly Diffusing Radiotracers for Tumor Imaging
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More in this TOC Section

  • 11C-Methionine PET of Myocardial Inflammation in a Rat Model of Experimental Autoimmune Myocarditis
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Keywords

  • immunoPET
  • 89Zr
  • 124I
  • prostate stem cell antigen (PSCA)
  • prostate cancer
  • minibody
  • antibody fragments
  • partial volume correction
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