Research ArticleBasic Science Investigations

Cerenkov Luminescence Endoscopy: Improved Molecular Sensitivity with β−-Emitting Radiotracers

Colin M. Carpenter, Xiaowei Ma, Hongguang Liu, Conroy Sun, Guillem Pratx, Jing Wang, Sanjiv S. Gambhir, Lei Xing and Zhen Cheng
Journal of Nuclear Medicine November 2014, 55 (11) 1905-1909; DOI: https://doi.org/10.2967/jnumed.114.139105

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    (A) Sensitivity comparison between 18F and 90Y. (B) Comparison between tracer SNR normalized for activity and light output, which is dependent on charged-particle energy.

  • FIGURE 2.
    FIGURE 2.

    (A and B) CLE emission (A) and CLE overlay (B) over ambient-light image of 18F vial covered with 1 cm of chicken breast. (C and D) CLE emission (C) and CLE overlay (D) over ambient-light image of 90Y vial covered with 1 cm of chicken breast. (E) Cross-sectional plot of line response of signal across 1 row of imaging fiber bundle, with 0 defined as optical axis. (F) Background noise (region outside vial containing radiotracer) in imaging fiber bundle vs. distance from vial to endoscope (in inches). a.u. = arbitrary units.

  • FIGURE 3.
    FIGURE 3.

    In vivo comparison of CLE improvement using 90Y-PRGD2 vs. 18F-FP-PRGD2. (A and B) Biodistribution results comparing tumor and muscle (A) and tumor-to-muscle (T/M) ratio (B) for both peptides. (C) Tumor-to-background ratio from 90Y-PRGD2 vs. 18F-FP-PRGD2 for all 4 mice as determined by CLE. (D and E) CLE image (D) and ambient-light overlay (E) of 90Y-PRGD2 emitted from mouse flank. (F and G) CLE image (F) and ambient-light overlay (G) of 18F-FP-PRGD2 emitted from mouse flank.

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