A Modular Labeling Strategy for In Vivo PET and Near-Infrared Fluorescence Imaging of Nanoparticle Tumor Targeting

Carlos Pérez-Medina; Dalya Abdel-Atti; Yachao Zhang; Valerie A. Longo; Chrisopher P. Irwin; Tina Binderup; Jesús Ruiz-Cabello; Zahi A. Fayad; Jason S. Lewis; Willem J.M. Mulder; Thomas Reiner

doi:10.2967/jnumed.114.141861

Research ArticleBasic Science Investigations

A Modular Labeling Strategy for In Vivo PET and Near-Infrared Fluorescence Imaging of Nanoparticle Tumor Targeting

Carlos Pérez-Medina, Dalya Abdel-Atti, Yachao Zhang, Valerie A. Longo, Chrisopher P. Irwin, Tina Binderup, Jesús Ruiz-Cabello, Zahi A. Fayad, Jason S. Lewis, Willem J.M. Mulder and Thomas Reiner

Journal of Nuclear Medicine October 2014, 55 (10) 1706-1711; DOI: https://doi.org/10.2967/jnumed.114.141861

Carlos Pérez-Medina

1Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain

2Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain

3Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York

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Dalya Abdel-Atti

4Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York

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Yachao Zhang

4Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York

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Valerie A. Longo

4Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York

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Chrisopher P. Irwin

4Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York

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Tina Binderup

3Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York

5Cluster for Molecular Imaging, Faculty of Health Sciences and Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen, Denmark

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Jesús Ruiz-Cabello

1Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain

2Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain

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Zahi A. Fayad

3Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York

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Jason S. Lewis

4Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York

6Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York; and

7Center for Molecular Imaging and Nanotechnology, Memorial Sloan-Kettering Cancer Center, New York, New York

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Willem J.M. Mulder

3Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York

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Thomas Reiner

4Radiochemistry and Imaging Sciences Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York

7Center for Molecular Imaging and Nanotechnology, Memorial Sloan-Kettering Cancer Center, New York, New York

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October 1, 2014

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A Modular Labeling Strategy for In Vivo PET and Near-Infrared Fluorescence Imaging of Nanoparticle Tumor Targeting

Carlos Pérez-Medina, Dalya Abdel-Atti, Yachao Zhang, Valerie A. Longo, Chrisopher P. Irwin, Tina Binderup, Jesús Ruiz-Cabello, Zahi A. Fayad, Jason S. Lewis, Willem J.M. Mulder, Thomas Reiner

Journal of Nuclear Medicine Oct 2014, 55 (10) 1706-1711; DOI: 10.2967/jnumed.114.141861

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A Modular Labeling Strategy for In Vivo PET and Near-Infrared Fluorescence Imaging of Nanoparticle Tumor Targeting

Carlos Pérez-Medina, Dalya Abdel-Atti, Yachao Zhang, Valerie A. Longo, Chrisopher P. Irwin, Tina Binderup, Jesús Ruiz-Cabello, Zahi A. Fayad, Jason S. Lewis, Willem J.M. Mulder, Thomas Reiner

Journal of Nuclear Medicine Oct 2014, 55 (10) 1706-1711; DOI: 10.2967/jnumed.114.141861

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