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Basic Science Investigations

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  Promising Prospects for ⁴⁴Sc-/⁴⁷Sc-Based Theragnostics: Application of ⁴⁷Sc for Radionuclide Tumor Therapy in Mice

  Cristina Müller, Maruta Bunka, Stephanie Haller, Ulli Köster, Viola Groehn, Peter Bernhardt, Nicholas van der Meulen, Andreas Türler and Roger Schibli

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1658-1664; DOI: https://doi.org/10.2967/jnumed.114.141614
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  Early Response Monitoring with ¹⁸F-FDG PET and Cetuximab-F(ab′)₂-SPECT After Radiotherapy of Human Head and Neck Squamous Cell Carcinomas in a Mouse Model

  Laura K. van Dijk, Otto C. Boerman, Gerben M. Franssen, Jasper Lok, Johannes H.A.M. Kaanders and Johan Bussink

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1665-1670; DOI: https://doi.org/10.2967/jnumed.114.141762
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  Preclinical Characterization of 5-Amino-4-Oxo-[6-¹¹C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

  Chie Suzuki, Atsushi B. Tsuji, Koichi Kato, Tatsuya Kikuchi, Hitomi Sudo, Maki Okada, Aya Sugyo, Ming-Rong Zhang, Yasushi Arano and Tsuneo Saga

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1671-1677; DOI: https://doi.org/10.2967/jnumed.114.145086
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  ^99mTc-cAbVCAM1-5 Imaging Is a Sensitive and Reproducible Tool for the Detection of Inflamed Atherosclerotic Lesions in Mice

  Alexis Broisat, Jakub Toczek, Laurent S. Dumas, Mitra Ahmadi, Sandrine Bacot, Pascale Perret, Lotfi Slimani, Gilles Barone-Rochette, Audrey Soubies, Nick Devoogdt, Tony Lahoutte, Daniel Fagret, Laurent M. Riou and Catherine Ghezzi

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1678-1684; DOI: https://doi.org/10.2967/jnumed.114.143792
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  Dynamic SPECT Measurement of Absolute Myocardial Blood Flow in a Porcine Model

  R. Glenn Wells, Rachel Timmins, Ran Klein, Julia Lockwood, Brian Marvin, Robert A. deKemp, Lihui Wei and Terrence D. Ruddy

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1685-1691; DOI: https://doi.org/10.2967/jnumed.114.139782
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  Detection of Increased ⁶⁴Cu Uptake by Human Copper Transporter 1 Gene Overexpression Using PET with ⁶⁴CuCl₂ in Human Breast Cancer Xenograft Model

  Kwang Il Kim, Su Jin Jang, Ju Hui Park, Yong Jin Lee, Tae Sup Lee, Kwang Sun Woo, Hyun Park, Jae Gol Choe, Gwang Il An and Joo Hyun Kang

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1692-1698; DOI: https://doi.org/10.2967/jnumed.114.141127
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  Oxidized Low-Density Lipoprotein Stimulates Macrophage ¹⁸F-FDG Uptake via Hypoxia-Inducible Factor-1α Activation Through Nox2-Dependent Reactive Oxygen Species Generation

  Su Jin Lee, Cung Hoa Thien Quach, Kyung-Ho Jung, Jin-Young Paik, Jin Hee Lee, Jin Won Park and Kyung-Han Lee

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1699-1705; DOI: https://doi.org/10.2967/jnumed.114.139428
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  A Modular Labeling Strategy for In Vivo PET and Near-Infrared Fluorescence Imaging of Nanoparticle Tumor Targeting

  Carlos Pérez-Medina, Dalya Abdel-Atti, Yachao Zhang, Valerie A. Longo, Chrisopher P. Irwin, Tina Binderup, Jesús Ruiz-Cabello, Zahi A. Fayad, Jason S. Lewis, Willem J.M. Mulder and Thomas Reiner

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1706-1711; DOI: https://doi.org/10.2967/jnumed.114.141861
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  Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys

  Olivier Barret, Jonas Hannestad, David Alagille, Christine Vala, Adriana Tavares, Caroline Papin, Thomas Morley, Krista Fowles, Hsiaoju Lee, John Seibyl, Dominique Tytgat, Marc Laruelle and Gilles Tamagnan

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1712-1718; DOI: https://doi.org/10.2967/jnumed.114.142067
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  N-Terminal Modifications Improve the Receptor Affinity and Pharmacokinetics of Radiolabeled Peptidic Gastrin-Releasing Peptide Receptor Antagonists: Examples of ⁶⁸Ga- and ⁶⁴Cu-Labeled Peptides for PET Imaging

  Eleni Gourni, Rosalba Mansi, Mazen Jamous, Beatrice Waser, Christiane Smerling, Antje Burian, Franz Buchegger, Jean Claude Reubi and Helmut R. Maecke

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1719-1725; DOI: https://doi.org/10.2967/jnumed.114.141242
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  Imaging the Evolution of Reactivation Pulmonary Tuberculosis in Mice Using ¹⁸F-FDG PET

  Allison M. Murawski, Saumya Gurbani, Jamie S. Harper, Mariah Klunk, Laurent Younes, Sanjay K. Jain and Bruno M. Jedynak

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1726-1729; DOI: https://doi.org/10.2967/jnumed.114.144634
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  Distinctive In Vivo Kinetics of the New σ₁ Receptor Ligands (R)-(+)- and (S)-(–)-¹⁸F-Fluspidine in Porcine Brain

  Peter Brust, Winnie Deuther-Conrad, Georg Becker, Marianne Patt, Cornelius K. Donat, Shannon Stittsworth, Steffen Fischer, Achim Hiller, Barbara Wenzel, Sladjana Dukic-Stefanovic, Swen Hesse, Jörg Steinbach, Bernhard Wünsch, Susan Z. Lever and Osama Sabri

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1730-1736; DOI: https://doi.org/10.2967/jnumed.114.137562
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  Feasibility of ¹⁸F-FDG PET as a Noninvasive Diagnostic Tool of Muscle Denervation: A Preliminary Study

  Seung Hak Lee, Byung-Mo Oh, Gangpyo Lee, Hongyoon Choi, Gi Jeong Cheon and Shi-Uk Lee

  Journal of Nuclear Medicine October 1, 2014, 55 (10) 1737-1740; DOI: https://doi.org/10.2967/jnumed.114.140731