Preclinical Characterization of 5-Amino-4-Oxo-[6-11C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

Chie Suzuki; Atsushi B. Tsuji; Koichi Kato; Tatsuya Kikuchi; Hitomi Sudo; Maki Okada; Aya Sugyo; Ming-Rong Zhang; Yasushi Arano; Tsuneo Saga

doi:10.2967/jnumed.114.145086

Research ArticleBasic Science Investigations

Preclinical Characterization of 5-Amino-4-Oxo-[6-¹¹C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

Chie Suzuki, Atsushi B. Tsuji, Koichi Kato, Tatsuya Kikuchi, Hitomi Sudo, Maki Okada, Aya Sugyo, Ming-Rong Zhang, Yasushi Arano and Tsuneo Saga

Journal of Nuclear Medicine October 2014, 55 (10) 1671-1677; DOI: https://doi.org/10.2967/jnumed.114.145086

Chie Suzuki

1Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

2Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

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Atsushi B. Tsuji

1Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

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Koichi Kato

3Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; and

4Department of Integrative Brain Imaging, National Center of Neurology and Psychiatry, Tokyo, Japan

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Tatsuya Kikuchi

3Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; and

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Hitomi Sudo

1Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

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Maki Okada

3Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; and

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Aya Sugyo

1Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

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Ming-Rong Zhang

3Molecular Probe Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; and

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Yasushi Arano

2Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

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Tsuneo Saga

1Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

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Preclinical Characterization of 5-Amino-4-Oxo-[6-¹¹C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

Chie Suzuki, Atsushi B. Tsuji, Koichi Kato, Tatsuya Kikuchi, Hitomi Sudo, Maki Okada, Aya Sugyo, Ming-Rong Zhang, Yasushi Arano, Tsuneo Saga

Journal of Nuclear Medicine Oct 2014, 55 (10) 1671-1677; DOI: 10.2967/jnumed.114.145086

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Preclinical Characterization of 5-Amino-4-Oxo-[6-¹¹C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

Chie Suzuki, Atsushi B. Tsuji, Koichi Kato, Tatsuya Kikuchi, Hitomi Sudo, Maki Okada, Aya Sugyo, Ming-Rong Zhang, Yasushi Arano, Tsuneo Saga

Journal of Nuclear Medicine Oct 2014, 55 (10) 1671-1677; DOI: 10.2967/jnumed.114.145086

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Keywords

5-aminolevulinic acid
photodynamic therapy
sonodynamic therapy
aminolevulinic acid dehydratase
11C-MALA

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