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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey

Su Jin Kim, Ming-Qiang Zheng, Nabeel Nabulsi, David Labaree, Jim Ropchan, Soheila Najafzadeh, Richard E. Carson, Yiyun Huang and Evan D. Morris
Journal of Nuclear Medicine September 2013, 54 (9) 1668-1674; DOI: https://doi.org/10.2967/jnumed.112.118877
Su Jin Kim
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
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Ming-Qiang Zheng
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
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Nabeel Nabulsi
1Yale PET Center, Yale University, New Haven, Connecticut
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David Labaree
1Yale PET Center, Yale University, New Haven, Connecticut
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Jim Ropchan
1Yale PET Center, Yale University, New Haven, Connecticut
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Soheila Najafzadeh
1Yale PET Center, Yale University, New Haven, Connecticut
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Richard E. Carson
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
3Department of Biomedical Engineering, Yale University, New Haven, Connecticut; and
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Yiyun Huang
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
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Evan D. Morris
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
3Department of Biomedical Engineering, Yale University, New Haven, Connecticut; and
4Department of Psychiatry, Yale University, New Haven, Connecticut
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Journal of Nuclear Medicine: 54 (9)
Journal of Nuclear Medicine
Vol. 54, Issue 9
September 1, 2013
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Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey
Su Jin Kim, Ming-Qiang Zheng, Nabeel Nabulsi, David Labaree, Jim Ropchan, Soheila Najafzadeh, Richard E. Carson, Yiyun Huang, Evan D. Morris
Journal of Nuclear Medicine Sep 2013, 54 (9) 1668-1674; DOI: 10.2967/jnumed.112.118877

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Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey
Su Jin Kim, Ming-Qiang Zheng, Nabeel Nabulsi, David Labaree, Jim Ropchan, Soheila Najafzadeh, Richard E. Carson, Yiyun Huang, Evan D. Morris
Journal of Nuclear Medicine Sep 2013, 54 (9) 1668-1674; DOI: 10.2967/jnumed.112.118877
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Cited By...

  • Impact of Pharmacological Manipulation of the {kappa}-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice
  • Receptor Occupancy of the {kappa}-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050
  • Test-Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the {kappa} Opioid Receptor
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More in this TOC Section

  • Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers
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Keywords

  • κ-opioid receptor
  • in vivo
  • selectivity
  • PET
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