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Research ArticleBasic Science Investigations

Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey

Su Jin Kim, Ming-Qiang Zheng, Nabeel Nabulsi, David Labaree, Jim Ropchan, Soheila Najafzadeh, Richard E. Carson, Yiyun Huang and Evan D. Morris
Journal of Nuclear Medicine September 2013, 54 (9) 1668-1674; DOI: https://doi.org/10.2967/jnumed.112.118877
Su Jin Kim
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
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Ming-Qiang Zheng
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
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Nabeel Nabulsi
1Yale PET Center, Yale University, New Haven, Connecticut
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David Labaree
1Yale PET Center, Yale University, New Haven, Connecticut
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Jim Ropchan
1Yale PET Center, Yale University, New Haven, Connecticut
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Soheila Najafzadeh
1Yale PET Center, Yale University, New Haven, Connecticut
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Richard E. Carson
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
3Department of Biomedical Engineering, Yale University, New Haven, Connecticut; and
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Yiyun Huang
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
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Evan D. Morris
1Yale PET Center, Yale University, New Haven, Connecticut
2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
3Department of Biomedical Engineering, Yale University, New Haven, Connecticut; and
4Department of Psychiatry, Yale University, New Haven, Connecticut
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Article Information

vol. 54 no. 9 1668-1674
DOI 
https://doi.org/10.2967/jnumed.112.118877
PubMed 
23918735

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 20, 2012
  • Accepted for publication April 8, 2013
  • Published online September 3, 2013.

Article Versions

  • previous version (August 5, 2013 - 05:34).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Su Jin Kim1,2,
  2. Ming-Qiang Zheng1,2,
  3. Nabeel Nabulsi1,
  4. David Labaree1,
  5. Jim Ropchan1,
  6. Soheila Najafzadeh1,
  7. Richard E. Carson1–3,
  8. Yiyun Huang1,2 and
  9. Evan D. Morris1–4
  1. 1Yale PET Center, Yale University, New Haven, Connecticut
  2. 2Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
  3. 3Department of Biomedical Engineering, Yale University, New Haven, Connecticut; and
  4. 4Department of Psychiatry, Yale University, New Haven, Connecticut
  1. For correspondence or reprints contact: Evan D. Morris, Departments of Diagnostic Radiology, Psychiatry, Biomedical Engineering, Yale University, 801 Howard Ave., New Haven, CT 06510. E-mail: evan.morris{at}yale.edu
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  • Novel Targets to Treat Depression: Opioid-Based Therapeutics
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Journal of Nuclear Medicine: 54 (9)
Journal of Nuclear Medicine
Vol. 54, Issue 9
September 1, 2013
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Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey
Su Jin Kim, Ming-Qiang Zheng, Nabeel Nabulsi, David Labaree, Jim Ropchan, Soheila Najafzadeh, Richard E. Carson, Yiyun Huang, Evan D. Morris
Journal of Nuclear Medicine Sep 2013, 54 (9) 1668-1674; DOI: 10.2967/jnumed.112.118877

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Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey
Su Jin Kim, Ming-Qiang Zheng, Nabeel Nabulsi, David Labaree, Jim Ropchan, Soheila Najafzadeh, Richard E. Carson, Yiyun Huang, Evan D. Morris
Journal of Nuclear Medicine Sep 2013, 54 (9) 1668-1674; DOI: 10.2967/jnumed.112.118877
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  • Impact of Pharmacological Manipulation of the {kappa}-Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice
  • Receptor Occupancy of the {kappa}-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050
  • Test-Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the {kappa} Opioid Receptor
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Keywords

  • κ-opioid receptor
  • in vivo
  • selectivity
  • PET
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