Research ArticleClinical Investigations

Acquisition Protocols and Correction Methods for Estimation of the Heart-to-Mediastinum Ratio in 123I-Metaiodobenzylguanidine Cardiac Sympathetic Imaging

Yusuke Inoue, Yutaka Abe, Yoshihiro Itoh, Yuji Asano, Kei Kikuchi, Yutaka Sakamoto, Keiji Matsunaga, Yutaka Ogino, Takahiro Iizuka and Hideki Mochizuki
Journal of Nuclear Medicine May 2013, 54 (5) 707-713; DOI: https://doi.org/10.2967/jnumed.112.111955

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Anterior chest images acquired using ME (A) and LEHR (B) methods in a 79-y-old man. H/M ratio was calculated as 3.41 and 2.13 by ME and LEHR methods, respectively.

  • FIGURE 2.
    FIGURE 2.

    Anterior chest images acquired using ME (A), LME20 (B), and LME15 (C) methods in a 75-y-old woman. H/M ratio was calculated as 3.70, 3.39, and 3.60 by ME, LME20, and LME15 methods, respectively.

  • FIGURE 3.
    FIGURE 3.

    Estimation of H/M ratios with no correction. (A) H/M ratios by non-ME methods, including LEHR, LME20, and LME15 methods, are plotted against those by ME method. Broken line represents line of identity. Regression equations and correlation coefficients are presented. (B) Errors by non-ME methods are plotted against H/M ratios by ME method.

  • FIGURE 4.
    FIGURE 4.

    Estimation of H/M ratios with empiric correction. (A) H/M ratios by non-ME methods, including LEHR, LME20, and LME15 methods, are plotted against those by ME method. H/M ratios by non-ME methods were corrected using empiric equation. Broken line represents line of identity. Regression equations and correlation coefficients are presented. (B) Errors by non-ME methods are plotted against H/M ratios by ME method.

  • FIGURE 5.
    FIGURE 5.

    Estimation of H/M ratios with IDW correction. (A) H/M ratios by non-ME methods, including LEHR, LME20, and LME15 methods, are plotted against those by ME method. H/M ratios by ME and non-ME methods were corrected by IDW method. Broken line represents line of identity. Regression equations and correlation coefficients are presented. (B) Errors by non-ME methods are plotted against H/M ratios by ME method.

Tables

  • TABLE 1

    Physical Characteristics of Collimators

    CharacteristicMELMELEHR
    System sensitivity at 10 cm (cps/MBq)139.6154.791.0
    System resolution at 10 cm (mm)12.510.47.4
    Penetration at 159 keV0.00%0.05%4.83%
    Penetration at 300 keV6.27%19.80%54.91%

    • System resolution is expressed as full width at half maximum.

  • TABLE 2

    Results of Estimation of H/M Ratios in LEHR Group

    H/M ratio
    CorrectionMELEHRError
    None2.02 ± 1.011.50 ± 0.44−0.52 ± 0.58
    Empiric2.02 ± 0.990.00 ± 0.18
    IDW2.10 ± 1.091.80 ± 0.79−0.30 ± 0.33

    • Data are mean ± SD.

  • TABLE 3

    Results of Estimation of H/M Ratios in LME Group

    H/M ratioError
    CorrectionMELME20LME15LME20LME15
    None2.36 ± 0.832.22 ± 0.732.31 ± 0.80−0.14 ± 0.10−0.05 ± 0.06
    Empiric2.36 ± 0.822.36 ± 0.820.00 ± 0.050.00 ± 0.05
    IDW2.47 ± 0.902.44 ± 0.902.53 ± 0.96−0.03 ± 0.060.05 ± 0.09

    • Data are mean ± SD.

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