Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals

Christine M. Sandiego; Xiao Jin; Tim Mulnix; Krista Fowles; David Labaree; Jim Ropchan; Yiyun Huang; Kelly Cosgrove; Stacy A. Castner; Graham V. Williams; Lisa Wells; Eugenii A. Rabiner; Richard E. Carson

doi:10.2967/jnumed.113.122077

Research ArticleBasic Science Investigations

Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABA_A-Benzodiazepine Binding with ¹¹C-Flumazenil in Awake and Anesthetized Animals

Christine M. Sandiego, Xiao Jin, Tim Mulnix, Krista Fowles, David Labaree, Jim Ropchan, Yiyun Huang, Kelly Cosgrove, Stacy A. Castner, Graham V. Williams, Lisa Wells, Eugenii A. Rabiner and Richard E. Carson

Journal of Nuclear Medicine November 2013, 54 (11) 1962-1968; DOI: https://doi.org/10.2967/jnumed.113.122077

Christine M. Sandiego

1Department of Biomedical Engineering, Yale University, New Haven, Connecticut

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Xiao Jin

1Department of Biomedical Engineering, Yale University, New Haven, Connecticut

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Tim Mulnix

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Krista Fowles

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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David Labaree

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Jim Ropchan

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Yiyun Huang

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Kelly Cosgrove

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

3Department of Psychiatry, Yale University, New Haven, Connecticut

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Stacy A. Castner

3Department of Psychiatry, Yale University, New Haven, Connecticut

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Graham V. Williams

3Department of Psychiatry, Yale University, New Haven, Connecticut

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Lisa Wells

4Imanova, Centre for Imaging Sciences, London, United Kingdom; and

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Eugenii A. Rabiner

4Imanova, Centre for Imaging Sciences, London, United Kingdom; and

5Centre for Neuroimaging Sciences, Institute of Psychiatry, Kings College, London, United Kingdom

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Richard E. Carson

1Department of Biomedical Engineering, Yale University, New Haven, Connecticut

2PET Center, Diagnostic Radiology, Yale University, New Haven, Connecticut

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Journal of Nuclear Medicine

Vol. 54, Issue 11

November 1, 2013

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Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABA_A-Benzodiazepine Binding with ¹¹C-Flumazenil in Awake and Anesthetized Animals

Journal of Nuclear Medicine Nov 2013, 54 (11) 1962-1968; DOI: 10.2967/jnumed.113.122077

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Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABA_A-Benzodiazepine Binding with ¹¹C-Flumazenil in Awake and Anesthetized Animals

Journal of Nuclear Medicine Nov 2013, 54 (11) 1962-1968; DOI: 10.2967/jnumed.113.122077

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flumazenil
isoflurane
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