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Research ArticleBasic Science Investigations

Initial Results of Simultaneous PET/MRI Experiments with an MRI-Compatible Silicon Photomultiplier PET Scanner

Hyun Suk Yoon, Guen Bae Ko, Sun Il Kwon, Chan Mi Lee, Mikiko Ito, In Chan Song, Dong Soo Lee, Seong Jong Hong and Jae Sung Lee
Journal of Nuclear Medicine April 2012, 53 (4) 608-614; DOI: https://doi.org/10.2967/jnumed.111.097501
Hyun Suk Yoon
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Guen Bae Ko
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Sun Il Kwon
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Chan Mi Lee
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Mikiko Ito
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In Chan Song
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Dong Soo Lee
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Seong Jong Hong
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Jae Sung Lee
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  • FIGURE 1.
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    FIGURE 1.

    SiPM detector module and shielding box.

  • FIGURE 2.
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    FIGURE 2.

    MRI-compatible SiPM PET scanner consisting of 12 detector modules.

  • FIGURE 3.
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    FIGURE 3.

    SiPM PET insert placed outside and inside 3-T MRI scanner.

  • FIGURE 4.
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    FIGURE 4.

    Flood maps of SiPM PET detector module acquired without (A) and with (B) application of radiofrequency pulse sequences, and profiles on them. Boxed regions are where profiles were estimated.

  • FIGURE 5.
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    FIGURE 5.

    T2-weighted MRI scans of uniform cylindric phantom acquired without (A) SiPM PET insert and with (B) insert (power on). Circled regions are where signal-to-noise ratio, summarized in Table 4, was estimated.

  • FIGURE 6.
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    FIGURE 6.

    Simultaneously acquired PET and MRI (T2-weighted turbo spin echo) scans of three 18F-filled capillary tubes inserted into cucumber.

  • FIGURE 7.
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    FIGURE 7.

    In vivo PET/MRI (T2-weighted turbo spin echo) study in BALB/c mouse after injection of 18F-FDG.

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    TABLE 1

    Specification of SiPM (MPPC S11064-050P)

    ParameterValue
    No. of channels16 (4 × 4)
    Effective area per channel (mm)3 × 3
    No. of pixels per channel3,600
    Pixel size (μm)50 × 50
    Fill factor (%)61.5
    Peak wavelength (nm)440
    Typical gain7.5 × 105
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    TABLE 2

    Major Characteristics of MRI-Compatible SiPM PET

    CharacteristicValue
    CrystalLGSO
    Size (mm3)1.5 × 1.5 × 7.0
    Pitch (mm)1.62
    No. per block360 (20 × 18)
    SiPMMPPC S11064-050P
    No. of channels16 (4 × 4)
    No. of channels per block64 (8 × 8)
    PET scanner
    No. of blocks12
    Ring diameter (cm)13.6
    Axial FOV (cm)3.2
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    TABLE 3

    Peak-to-Valley Ratio Along Profiles on Middle Rows in Flood Maps Shown in Figure 4

    ParameterWithout radiofrequencyWith radiofrequency
    Mean3.503.49
    SD0.971.03
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    TABLE 4

    Summary of Average Signal Intensity and Signal-to-Noise Ratio of MRI Scans Shown in Figure 5

    ParameterWithout PETWith PET
    Intensity1,0021,006
    Signal-to-noise ratio27.123.4

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Journal of Nuclear Medicine: 53 (4)
Journal of Nuclear Medicine
Vol. 53, Issue 4
April 1, 2012
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Initial Results of Simultaneous PET/MRI Experiments with an MRI-Compatible Silicon Photomultiplier PET Scanner
Hyun Suk Yoon, Guen Bae Ko, Sun Il Kwon, Chan Mi Lee, Mikiko Ito, In Chan Song, Dong Soo Lee, Seong Jong Hong, Jae Sung Lee
Journal of Nuclear Medicine Apr 2012, 53 (4) 608-614; DOI: 10.2967/jnumed.111.097501

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Initial Results of Simultaneous PET/MRI Experiments with an MRI-Compatible Silicon Photomultiplier PET Scanner
Hyun Suk Yoon, Guen Bae Ko, Sun Il Kwon, Chan Mi Lee, Mikiko Ito, In Chan Song, Dong Soo Lee, Seong Jong Hong, Jae Sung Lee
Journal of Nuclear Medicine Apr 2012, 53 (4) 608-614; DOI: 10.2967/jnumed.111.097501
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