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Journal of Nuclear Medicine

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Research ArticleFocus on Molecular Imaging

In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection

Erik H.J.G. Aarntzen, Mangala Srinivas, Piotr Walczak, Miroslaw Janowski, Arend Heerschap, I. Jolanda M. de Vries, Carl G. Figdor, Jeff W.M. Bulte and Wim J.G. Oyen
Journal of Nuclear Medicine December 2012, 53 (12) 1825-1828; DOI: https://doi.org/10.2967/jnumed.112.106146
Erik H.J.G. Aarntzen
1Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
2Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
3Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Mangala Srinivas
1Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Piotr Walczak
4Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Miroslaw Janowski
4Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland
5NeuroRepair Department, MMRC, PAS, Warsaw, Poland
6Department of Neurosurgery, MMRC, PAS, Warsaw, Poland; and
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Arend Heerschap
7Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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I. Jolanda M. de Vries
1Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
2Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Carl G. Figdor
1Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Jeff W.M. Bulte
4Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Wim J.G. Oyen
3Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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  • FIGURE 1.
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    FIGURE 1.

    Cellular therapy offers hope for treatment of today’s most prevalent diseases, including cancer and cardiovascular diseases. Transplanted therapeutic cells essentially perform 3 main roles: regeneration, replacement, and redirection. Imaging protocols should serve different functions in each of these, that is, emphasizing specific aspects of cellular therapy in order to optimize therapeutic strategies. Important factors for consideration are sensitivity, patient discomfort, exposure to radiation, and minimization of cost.

  • FIGURE 2.
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    FIGURE 2.

    In vivo scintigraphy and MRI cell tracking of dendritic cells labeled with superparamagnetic iron oxide and 111In after intranodal injection. (Left) Gradient echo coronal MR image showing 2 left inguinal lymph nodes with hypointense signal area 48 h after injection. (Right) Corresponding scintigraphic image including quantification of relative cellular distribution among multiple lymph nodes. Arrows indicate 2 parts that belong to same lymph node.

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Journal of Nuclear Medicine: 53 (12)
Journal of Nuclear Medicine
Vol. 53, Issue 12
December 1, 2012
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In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection
Erik H.J.G. Aarntzen, Mangala Srinivas, Piotr Walczak, Miroslaw Janowski, Arend Heerschap, I. Jolanda M. de Vries, Carl G. Figdor, Jeff W.M. Bulte, Wim J.G. Oyen
Journal of Nuclear Medicine Dec 2012, 53 (12) 1825-1828; DOI: 10.2967/jnumed.112.106146

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In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection
Erik H.J.G. Aarntzen, Mangala Srinivas, Piotr Walczak, Miroslaw Janowski, Arend Heerschap, I. Jolanda M. de Vries, Carl G. Figdor, Jeff W.M. Bulte, Wim J.G. Oyen
Journal of Nuclear Medicine Dec 2012, 53 (12) 1825-1828; DOI: 10.2967/jnumed.112.106146
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  • Article
    • Abstract
    • REGENERATION
    • REPLACEMENT
    • REDIRECTION
    • CONCLUSION
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Keywords

  • in vivo imaging
  • tracking
  • cellular therapy
  • transplantation
  • regenerative medicine
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