Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Meeting ReportInstrumentation & Data Analysis: Data Analysis & Management

Optimizing PET scan protocol for small animal study: Correlation between scan duration, injected activity, target dimension, target-to-background ratio and imaging performance

Ching-Ching Yang
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 2087;
Ching-Ching Yang
1Department of Radiological Technology, Tzu-Chi College of Technology, Hualien, Taiwan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

2087

Objectives Increasing the injected activity or the scanning duration is usually considered to achieve target imaging performance in an animal PET study, but may thus affect the processes under study due to the increased radiation and anesthetic dose. The aim of this study was to investigate how PET image quality behave when varying scan duration and injected activity.

Methods PET data sets of a cylindric water phantom (4 cm in diameter and 8.2 cm in height) including spheres with different object properties were simulated using the GATE Monte Carlo simulation software. A multivariate approach was used to investigate the simultaneous effects of target dimension (Dtarg = 4, 5, 6, 8, 12 mm in diameter), target-to-background ratio (T/B ratio = 2, 4, 8, 12, 20), scan duration (Tacq = 30, 60, 90 min) and injected activity (Aacq = 4.7×104, 9.3×104, 1.4×105 Bq/ml) on contrast-to-noise ratio (CNR) and background variability (BV).

Results The T/B ratio resulted as the most significant predictor of CNR, followed by Dtarg, Tacq and Aacq of the given sphere. Dtarg, Tacq and Aacq were the most important, the second most important and the least important predictor of BV, respectively. The fittings of both models were good with R2 larger than 0.80 in both cases.

Conclusions Our preliminary results should provide practical guidance on how to define appropriate scan duration and radioactivity to achieve the target imaging performance when imaging object with different intrinsic characteristics

Back to top

In this issue

Journal of Nuclear Medicine
Vol. 52, Issue supplement 1
May 2011
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Optimizing PET scan protocol for small animal study: Correlation between scan duration, injected activity, target dimension, target-to-background ratio and imaging performance
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Optimizing PET scan protocol for small animal study: Correlation between scan duration, injected activity, target dimension, target-to-background ratio and imaging performance
Ching-Ching Yang
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 2087;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Optimizing PET scan protocol for small animal study: Correlation between scan duration, injected activity, target dimension, target-to-background ratio and imaging performance
Ching-Ching Yang
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 2087;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Instrumentation & Data Analysis: Data Analysis & Management

  • A website for voxel dosimetry: Free databases and on-line calculations of voxel S values
  • Residual activity correction for computing myocardial blood flow from dynamic 13NH3 studies
  • Improved reproducibility of heart-to-mediastinum ratio by semi-automatic calculation algorithm in cardiac I-123 MIBG imaging
Show more Instrumentation & Data Analysis: Data Analysis & Management

Data Analysis and Management Posters

  • A website for voxel dosimetry: Free databases and on-line calculations of voxel S values
  • Residual activity correction for computing myocardial blood flow from dynamic 13NH3 studies
  • Improved reproducibility of heart-to-mediastinum ratio by semi-automatic calculation algorithm in cardiac I-123 MIBG imaging
Show more Data Analysis and Management Posters

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire