Research ArticleBasic Science Investigation

Total Abdominal 18F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

Dianne M. Heijink, Jan H. Kleibeuker, Wouter B. Nagengast, Dorenda Oosterhuis, Adrienne H. Brouwers, Jan J. Koornstra, Steven de Jong and Elisabeth G.E. de Vries
Journal of Nuclear Medicine March 2011, 52 (3) 431-436; DOI: https://doi.org/10.2967/jnumed.110.083956

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Whole-body 18F-FDG PET images of ApcMin mouse at age 12 wk. VOI to calculate abdominal uptake of tracer is shown in orange.

  • FIGURE 2.
    FIGURE 2.

    (A) Whole-body 18F-FDG PET images of ApcMin mouse at age 12 wk. Abdominal hot spots most likely reflecting intestinal adenomas are indicated by arrows. (B) 18F-FDG PET of intestines of ApcMin mouse at age 12 wk. Large arrows indicate large adenomas (≥2 mm), and small arrows indicate small adenomas (<2 mm). Schematic representation of microscopic view of intestine with adenomas is shown below 18F-FDG PET image.

  • FIGURE 3.
    FIGURE 3.

    (A) Ex vivo intestinal 18F-FDG uptake expressed as percentage of whole-body 18F-FDG uptake in ApcMin mice aged 9 (n = 4) and 12 (n = 4) wk. Mean and SD are displayed. (B) In vivo abdominal 18F-FDG uptake expressed as percentage of whole-body 18F-FDG uptake in ApcMin mice aged 9 (n = 4) and 12 (n = 4) wk. Mean and SD are displayed. (C) Correlation between ex vivo intestinal 18F-FDG uptake and in vivo abdominal 18F-FDG uptake in 4 ApcMin mice aged 9 wk and 4 ApcMin mice aged 12 wk. (D) Correlation between ex vivo intestinal 18F-FDG uptake and number of large intestinal adenomas based on microscopy in 4 ApcMin mice aged 9 wk and 4 ApcMin mice aged 12 wk. *P < 0.05.

  • FIGURE 4.
    FIGURE 4.

    (A) Correlation between in vivo abdominal 18F-FDG uptake and number of large intestinal adenomas in 4 ApcMin mice aged 12 wk that were fed purified diet. (B) Correlation between in vivo abdominal 18F-FDG uptake and number of large intestinal adenomas in 5 ApcMin mice aged 12 wk that were fed standard chow.

Tables

  • TABLE 1

    Adenoma Number in ApcMin Mice (Age, 9 and 12 Weeks) Fed Purified Diet

    Age (wk)P (9 vs.12 wk)
    Number of…912
    Adenomas0.39
     Mean ± SD26 ± 6.221.25 ± 8.2
     Range19–3312–30
    Adenomas ≥ 2 mm0.81
     Mean ± SD6.25 ± 2.25.75 ± 2.2
     Range4–113–8
  • TABLE 2

    Adenoma Number in ApcMin Mice (Age, 6, 8, 10, and 12 Weeks) Fed Standard Chow

    Age (wk)
    Number of…681012P (10 vs. 12 wk)
    Adenomas0.02
     Mean ± SD19.2 ± 3.932 ± 959.6 ± 14.434.8 ± 10.8
     Range19–2323–4144–8217–46
    Adenomas ≥ 2 mm0.96
     Mean ± SD01.3 ± 0.614 ± 5.014.2 ± 7
     Range01–29–205–24
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