Article Figures & Data
Figures
- FIGURE 1.
Time–activity curves for source organs after 11C-NOP-1A injection at baseline and after receptor blockade with SB-612111. Symbols represent mean from 3 monkeys and are same for each of 3 pairs of panels (baseline and blocked). Data are decay-corrected to time of injection.
- FIGURE 2.
Representative time–activity curves of 11C-NOP-1A in plasma and brain at baseline and after receptor blockade with SB-612111 in single monkey. (A) 11C-NOP-1A concentration, separated from radiometabolites, in arterial plasma is plotted at baseline (▴) and after receptor blockade (▵). Values from 0 to 6 min and from 20 to 100 min are plotted on separate graphs, which differ in range of y-axis. (B) Concentrations of radioactivity in occipital cortex after injection of 11C-NOP-1A are shown at baseline (•) and after receptor blockade (○). Measured brain data were fit with 1-tissue (solid line) and 2-tissue (dotted line)-compartment models. At baseline conditions, 2 fittings overlap almost completely.
- FIGURE 3.
Transaxial PET images of brain uptake at baseline and after receptor blockade in same monkey. PET images from 40 to 80 min after injection of 11C-NOP-1A were summed, and pixel values represent mean concentration of radioactivity (standardized uptake value). Monkey was injected with 222 MBq of 11C-NOP-1A at baseline and 222 MBq after receptor blockade. Radioactivity concentration was expressed as standardized uptake value (SUV), which normalizes for injected activity and body mass. Coregistered MR image shows that PET slice extends through caudate, putamen, and cerebellum.
Tables
Target organ Radiation dose (μGy/MBq) Adrenals 3.4 Brain 5.5 Breasts 1.9 Gallbladder wall 35.6 Lower large intestine wall 2.4 Small intestine 4.1 Stomach wall 2.6 Upper large intestine wall 2.8 Heart wall 12.8 Kidneys 13.5 Liver 13.8 Lungs 11.2 Muscle 2.1 Ovaries 2.5 Pancreas 3.5 Red marrow 5.0 Osteogenic cells 4.5 Skin 1.5 Spleen 11.9 Testes 1.8 Thymus 2.3 Thyroid 1.9 Urinary bladder wall 15.7 Uterus 2.8 Total body 2.8 Effective dose (μSv/MBq) 5.0 VT (mL · cm−3) Baseline Blocked Organ Mean SD Mean SD VS (mL · cm−3), baseline − blocked VS/VT (%) Prefrontal cortex 18.1 0.9 6.6 2.3 11.6 64 Basal frontal cortex 16.6 1.0 6.1 1.7 10.5 63 Parietal cortex 19.3 2.5 6.8 2.2 12.5 65 Occipital cortex 20.4 2.2 6.6 1.8 13.7 67 Insula 19.8 2.2 7.5 1.9 12.3 62 Lateral temporal cortex 21.3 1.0 7.2 2.0 14.2 66 Medial temporal cortex 16.5 1.3 6.6 1.2 9.9 60 Amygdala 21.0 3.7 7.3 1.8 13.7 65 Hippocampus 18.1 3.0 7.1 1.5 11.0 61 Anterior cingulate 17.7 1.4 7.4 1.8 10.3 58 Posterior cingulate 17.6 1.4 7.2 1.8 10.4 59 Caudate 15.3 0.2 7.2 1.9 8.1 53 Putamen 16.0 1.3 7.6 1.9 8.5 53 Thalamus 16.2 0.7 8.0 2.0 8.2 51 Hypothalamus 12.6 1.2 7.4 1.8 5.2 41 Cerebellum 12.9 1.1 6.7 1.4 6.2 48
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