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Research ArticleBasic Science Investigations

Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors

Yasuyuki Kimura, Masahiro Fujita, Jinsoo Hong, Talakad G. Lohith, Robert L. Gladding, Sami S. Zoghbi, Johannes A. Tauscher, Nancy Goebl, Karen S. Rash, Zhaogen Chen, Concepcion Pedregal, Vanessa N. Barth, Victor W. Pike and Robert B. Innis
Journal of Nuclear Medicine October 2011, 52 (10) 1638-1645; DOI: https://doi.org/10.2967/jnumed.111.091181
Yasuyuki Kimura
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Masahiro Fujita
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Jinsoo Hong
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Talakad G. Lohith
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Robert L. Gladding
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Sami S. Zoghbi
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Johannes A. Tauscher
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Nancy Goebl
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Karen S. Rash
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Zhaogen Chen
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Concepcion Pedregal
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Vanessa N. Barth
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Victor W. Pike
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Robert B. Innis
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Article Information

vol. 52 no. 10 1638-1645
DOI 
https://doi.org/10.2967/jnumed.111.091181
PubMed 
21880575

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication March 31, 2011
  • Accepted for publication June 20, 2011
  • Published online October 3, 2011.

Article Versions

  • previous version (August 30, 2011 - 05:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2011 by Society of Nuclear Medicine

Author Information

  1. Yasuyuki Kimura1,2,
  2. Masahiro Fujita1,
  3. Jinsoo Hong1,
  4. Talakad G. Lohith1,
  5. Robert L. Gladding1,
  6. Sami S. Zoghbi1,
  7. Johannes A. Tauscher3,
  8. Nancy Goebl3,
  9. Karen S. Rash3,
  10. Zhaogen Chen3,
  11. Concepcion Pedregal3,
  12. Vanessa N. Barth3,
  13. Victor W. Pike1 and
  14. Robert B. Innis1
  1. 1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
  2. 2Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; and
  3. 3Eli Lilly and Co., Indianapolis, Indiana
  1. For correspondence or reprints contact: Robert B. Innis, Molecular Imaging Branch, National Institute of Mental Health, 10 Center Dr., Bethesda, MD 20892-1026. E-mail: robert.innis{at}nih.gov
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Cited By...

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  • The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence
    Jeffrey M. Witkin, Michael A. Statnick, Linda M. Rorick-Kehn, John E. Pintar, Michael Ansonoff, Yanyun Chen, R. Craig Tucker, Roberto Ciccocioppo
    Pharmacology & Therapeutics 2014 141 3
  • Functional plasticity of theN/OFQ‐NOPreceptor system determines analgesic properties ofNOPreceptor agonists
    W Schröder, D G Lambert, M C Ko, T Koch
    British Journal of Pharmacology 2014 171 16
  • Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility
    Nurulain T. Zaveri
    Journal of Medicinal Chemistry 2016 59 15
  • A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies
    Anke Post, Trevor S Smart, Judith Krikke-Workel, Gerard R Dawson, Catherine J Harmer, Michael Browning, Kimberley Jackson, Rishi Kakar, Richard Mohs, Michael Statnick, Keith Wafford, Andrew McCarthy, Vanessa Barth, Jeffrey M Witkin
    Neuropsychopharmacology 2016 41 7
  • Targeting opioid dysregulation in depression for the development of novel therapeutics
    Caroline A. Browne, Irwin Lucki
    Pharmacology & Therapeutics 2019 201
  • The Therapeutic Potential of Nociceptin/Orphanin FQ Receptor Agonists as Analgesics without Abuse Liability
    Ann P. Lin, Mei-Chuan Ko
    ACS Chemical Neuroscience 2013 4 2
  • Brain and Whole-Body Imaging of Nociceptin/Orphanin FQ Peptide Receptor in Humans Using the PET Ligand 11C-NOP-1A
    Talakad G. Lohith, Sami S. Zoghbi, Cheryl L. Morse, Maria F. Araneta, Vanessa N. Barth, Nancy A. Goebl, Johannes T. Tauscher, Victor W. Pike, Robert B. Innis, Masahiro Fujita
    Journal of Nuclear Medicine 2012 53 3
  • A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models
    Linda M. Rorick-Kehn, Roberto Ciccocioppo, Conrad J. Wong, Jeffrey M. Witkin, Maria A. Martinez-Grau, Serena Stopponi, Benjamin L. Adams, Jason S. Katner, Kenneth W. Perry, Miguel A. Toledo, Nuria Diaz, Celia Lafuente, Alma Jiménez, Ana Benito, Concepción Pedregal, Friedbert Weiss, Michael A. Statnick
    Alcoholism: Clinical and Experimental Research 2016 40 5
  • The opioid system in depression
    Luke A. Jelen, James M. Stone, Allan H. Young, Mitul A. Mehta
    Neuroscience & Biobehavioral Reviews 2022 140
  • Chronic Treatment with Novel Brain-Penetrating Selective NOP Receptor Agonist MT-7716 Reduces Alcohol Drinking and Seeking in the Rat
    Roberto Ciccocioppo, Serena Stopponi, Daina Economidou, Makoto Kuriyama, Hiroshi Kinoshita, Markus Heilig, Marisa Roberto, Friedbert Weiss, Koji Teshima
    Neuropsychopharmacology 2014 39 11

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Journal of Nuclear Medicine: 52 (10)
Journal of Nuclear Medicine
Vol. 52, Issue 10
October 1, 2011
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Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors
Yasuyuki Kimura, Masahiro Fujita, Jinsoo Hong, Talakad G. Lohith, Robert L. Gladding, Sami S. Zoghbi, Johannes A. Tauscher, Nancy Goebl, Karen S. Rash, Zhaogen Chen, Concepcion Pedregal, Vanessa N. Barth, Victor W. Pike, Robert B. Innis
Journal of Nuclear Medicine Oct 2011, 52 (10) 1638-1645; DOI: 10.2967/jnumed.111.091181

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Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors
Yasuyuki Kimura, Masahiro Fujita, Jinsoo Hong, Talakad G. Lohith, Robert L. Gladding, Sami S. Zoghbi, Johannes A. Tauscher, Nancy Goebl, Karen S. Rash, Zhaogen Chen, Concepcion Pedregal, Vanessa N. Barth, Victor W. Pike, Robert B. Innis
Journal of Nuclear Medicine Oct 2011, 52 (10) 1638-1645; DOI: 10.2967/jnumed.111.091181
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  • Brain and Whole-Body Imaging of Nociceptin/Orphanin FQ Peptide Receptor in Humans Using the PET Ligand 11C-NOP-1A
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