Article Figures & Data
Figures
- FIGURE 1.
(A and B) Coronal PET/CT images of woodchuck model of HCC: 18F-FDG image taken at 60 min after injection (A) and 11C-choline image taken at 30 min after injection (B). Two HCC nodules are indicated by dotted rings and arrow. (C and D) H&E-stained sections (×400): surrounding hepatic tissue (C) and region within dotted rings (D).
- FIGURE 2.
(A) Coronal PET/CT image of woodchuck model of well-differentiated HCC. Image was obtained 30 min after injection of 11C-choline. Green dotted rings indicate clear cell HCC, red dotted ring indicates compact-type HCC, and arrow indicates surrounding hepatic tissue. (B and C) H&E-stained sections (×400): region within green dotted rings (B) and region within red dotted ring (C).
- FIGURE 3.
Metabolite analysis of woodchuck model of HCC using 14C-choline. Distribution of 14C activity between HCCs and surrounding hepatic tissues (A) and pattern of 14C-choline metabolites in water- and lipid-soluble phases from woodchuck models of HCC (B). *P < 0.05.
- FIGURE 4.
Choline kinase activity in woodchuck model of HCC. †P < 0.05. ‡P < 0.05.
- FIGURE 5.
Activation of CTP:phosphocholine cytidylyltransferase by 1 mM oleic acid. *P < 0.05. **P < 0.05.
Tables
Phosphatidylethanolamine methylation pathway Time after injection CDP-choline pathway (Rf = 0.45–0.50) Rf = 0.30–0.35 Rf = 0.15–0.18 HCCs 12 min 80.86 ± 10.45*† (n = 34) 11.98 ± 4.75* (n = 34) 7.30 ± 8.16† (n = 34) 30 min 95.6 ± 5.4‡ (n = 39) 4.4 ± 1.4‡ (n = 39) ND Surrounding hepatic tissues 12 min 52.6 ± 11.9 (n = 6) ND 48.4 ± 12.4 (n = 6) 30 min 100 ± 0 (n = 15) ND ND
Supplemental Data
Files in this Data Supplement:
