Research ArticleCLINICAL INVESTIGATIONS

18F-FDG PET of Locally Invasive Breast Cancer and Association of Estrogen Receptor Status with Standardized Uptake Value: Microarray and Immunohistochemical Analysis

Joseph R. Osborne, Elisa Port, Mithat Gonen, Ashley Doane, Henry Yeung, William Gerald, Josh B. Cook and Steven Larson
Journal of Nuclear Medicine April 2010, 51 (4) 543-550; DOI: https://doi.org/10.2967/jnumed.108.060459

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    (A) 18F-FDG accumulation correlates weakly with tumor size. (B–D) Neither HER2 status (B), node status (C), nor PR status (D) correlates with maximum SUV. (E) Accumulation does correlate with ER status. Open circles denote tumor samples subjected to microarray analysis. Closed circles do not have gene profiles.

  • FIGURE 2. 
    FIGURE 2. 

    Twenty tumors clustered into 2 groups of 10 each on basis of genomewide expression profile. (A) Complete gene list. (B) ER and ER-related genes were main grouping discriminators.

  • FIGURE 3. 
    FIGURE 3. 

    Overlap between validated ER status gene list (generated from tumor bank of 99 women) and the 500 genes whose expression most correlated with SUV from our sample of 20 tumors (P < 0.001).

Tables

  • TABLE 1

    A Select Subset of Genes That Most Correlated with Increased Tumor 18F-FDG Uptake

    RankSUV correlationDescription
    40.817High-affinity aspartate glutamate transporter member 6 (SLAC1A6) mRNA
    50.815Thymosin β identified in neuroblastoma cells (TMSNB) mRNA
    80.793Human galactosyltransferase–associated protein kinase (p58GTA) mRNA
    9−0.788Subunit B (B56)
    230.751Orosomucoid 1 (ORM1) mRNA
    250.749Transmembrane phosphatase with tensin homology (TPTE) mRNA
    260.746Orosomucoid 2 (ORM2) mRNA
    280.739TTK protein kinase mRNA
    330.732Mitotic spindle-coiled coil-related protein (DEEPEST) mRNA
    350.729Ubiquitin-conjugating enzyme E2A (RAD6 homolog) (UBE2A) mRNA
    430.717Malic enzyme 1, NADP(+)-dependent cytosolic (ME1) mRNA
    500.711Cellular retinoic acid–binding protein 1 (CRABP1) mRNA
    590.707Regulator of G protein signaling-Z (RGSZ1) mRNA
    780.692Hexokinase 3 (white cell) (HK3) mRNA
    880.685Ubiquitin-conjugating enzyme E2D
    970.679L-type amino acid transporter 1
    345−0.597Facilitated glucose transporter member 8 (SLC2A8) mRNA
    1,5820.515Human CDC6-related protein (HsCDC6) mRNA
    6,1370.334Homo sapiens centromere protein F (CENPF) mRNA

    • mRNA = messenger RNA.

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