Article Figures & Data
Figures
- FIGURE 1.
Cardiac death-free survival curves for median values of MPR tertiles are shown. Median MPR values of each tertile (intertertile boundaries, 1.49 and 1.84) were taken to illustrate differences between these groups. Numbers indicate patients at risk and number of events per tertile (T).
- FIGURE 2.
Hazard ratio curves and percentage distribution for MPR (A) and for LVEF (B).
Tables
Characteristic MPR, first tertile (<1.49) (n = 114) MPR, second tertile (1.49–1.84) (n = 116) MPR, third tertile (>1.84) (n = 114) Total (n = 344) P Age (y) 69 ± 11 68 ± 10 62 ± 11 66 ± 11 <0.001 Sex (F/M) (n) 22/92 26/90 25/89 73/271 0.628 Hypercholesterolemia (%) 54 53 64 57 0.141 Smoking (%) 31 28 38 33 0.323 Diabetes mellitus (%) 12 17 10 13 0.539 Hypertension (%) 28 29 29 29 0.884 Family history (%) 32 40 54 42 0.001 Previous myocardial infarction (%) 82 71 61 71 <0.001 Previous CABG (%) 29 31 26 29 0.661 Previous PCI (n) 44 42 48 45 0.506 LVEF (%) 30 ± 14 37 ± 13 41 ± 17 36 ± 15 <0.001 Typical anginal complaints (%) 77 85 81 81 0.747 Left ventricular end-diastolic volume (mL) 172 ± 91 124 ± 62 124 ± 81 140 ± 82 <0.001 Aspirin (%) 54 68 68 63 0.040 Coumarin (%) 44 29 25 33 0.003 Statin (%) 52 48 61 54 0.185 Diuretic (%) 47 31 24 34 <0.001 Digoxin (%) 22 11 8 14 0.002 β-blocker (%) 64 70 60 65 0.489 Angiotensin-converting enzyme-inhibitor/ARB (%) 58 40 42 47 0.017 Matching defect (% left ventricle) 30 ± 15 27 ± 15 25 ± 17 27 ± 16 0.012 Location of matching defects: LAD/LCX/RCA area (%) 29/33/44 34/30/55 32/18/51 31/27/50 0.669/0.007/0.290 Mismatching defect (% left ventricle) 11 ± 10 8 ± 10 7 ± 9 9 ± 10 0.011 Location of mismatching defects: LAD/LCX/RCA area (%) 27/37/33 26/24/28 14/33/22 22/31/28 0.017/0.393/0.055 Normal area of left ventricle (%) 59 ± 19 65 ± 19 68 ± 21 64 ± 20 0.001 Myocardial perfusion at rest (mL/min/100 g) 96 ± 23 85 ± 22 80 ± 21 87 ± 23 <0.001 Myocardial perfusion during stress (mL/min/100 g) 117 ± 34 139 ± 36 177 ± 45 145 ± 46 <0.001 ARB = angiotensin type I receptor blocker; LAD = left anterior descending coronary artery; LCX = circumflex coronary artery; RCA = right coronary artery.
Categoric variables are show as percentage or as number; continuous variables as mean ± SD.
- TABLE 2
Univariate and Multivariate Cox Proportional Hazard Regression Analysis of Cardiac Death According to MPR
Univariate analysis Age- and sex-adjusted analysis Variable Hazard ratio P Hazard ratio P MPR (per SD) 4.18 (3.05–5.74) <0.001 4.11 (2.98–5.67) <0.001 Family history (yes) 0.56 (0.32–0.98) 0.043 0.68 (0.38−1.21) 0.191 Previous myocardial infarction (yes) 6.06 (2.20–16.71) 0.001 5.21 (1.87–14.54) 0.002 LVEF (per SD) 2.79 (2.02–3.85) <0.001 2.76 (2.00–3.82) <0.001 LVEDV (per 10 mL) 1.05 (1.03–1.08) <0.001 1.06 (1.04–1.08) <0.001 Aspirin (yes) 0.41 (0.24–0.67) 0.001 0.40 (0.24–0.68) <0.001 Diuretics (yes) 5.58 (3.17–9.81) <0.001 5.58 (3.15–9.91) <0.001 Digoxin (yes) 4.97 (2.94–8.39) <0.001 4.94 (2.90–8.40) <0.001 Matching (per 10%) 1.40 (1.20–1.64) <0.001 1.41 (1.20–1.66) <0.001 Mismatching (per 10%) 1.20 (0.95–1.51) 0.134 1.16 (0.91–1.50) 0.226 CI = confidence interval; LVEDV = left ventricular end-diastolic volume.
Data in parentheses are 95% confidence intervals.
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