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Research ArticleCLINICAL INVESTIGATIONS

Impact of 131I SPECT/Spiral CT on Nodal Staging of Differentiated Thyroid Carcinoma at the First Radioablation

Daniela Schmidt, Attila Szikszai, Rainer Linke, Werner Bautz and Torsten Kuwert
Journal of Nuclear Medicine January 2009, 50 (1) 18-23; DOI: https://doi.org/10.2967/jnumed.108.052746
Daniela Schmidt
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Attila Szikszai
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Rainer Linke
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Werner Bautz
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Torsten Kuwert
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  • FIGURE 1. 
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    FIGURE 1. 

    A 54-y-old woman with differentiated papillary thyroid carcinoma (pT2 N1a [6/21] Mx) after total thyroidectomy and lymph node dissection of centrocervical and left lateral compartment. (A) Planar scintigraphy shows two 131I-avid foci interpreted as thyroid remnant. (B) SPECT/CT (left column) and CT (right column) demonstrate that these foci correspond to LNMs in superior mediastinum (level VII)—shown here for right focus.

  • FIGURE 2. 
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    FIGURE 2. 

    A 30-y-old woman with differentiated papillary thyroid carcinoma (pT2 N0 [0/10] Mx) after total thyroidectomy and lymph node dissection of centrocervical compartment. (A) Planar scintigraphy shows large 131I-avid foci interpreted as thyroid remnant and indeterminate. (B) SPECT/CT fusion images (left column) and CT (right column) demonstrate 1 focus corresponding to LNM in level II. (C) SPECT/CT (left column) and CT (right column) demonstrate 1 focus corresponding to LNM in level III.

  • FIGURE 3. 
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    FIGURE 3. 

    A 43-y-old woman with differentiated papillary thyroid carcinoma (pT1 N0 [0/7] Mx) after total thyroidectomy and lymph node dissection of centrocervical compartment. (A) Planar scintigraphy shows 131I-avid foci interpreted as LNMs (arrows) and thyroid remnant. (B) SPECT/CT fusion images (left column) and CT (right column) demonstrate that these foci correspond to LNMs in level II and level IV—shown here for lower focus.

  • FIGURE 4. 
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    FIGURE 4. 

    Imaging results in patients classified as N0 (A) or Nx (B) by histopathology. “Nx” denotes classification as indeterminate.

Tables

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    TABLE 1

    Tumor Stage and TNM Classification as Defined by AJCC/UICC in the Patients Studied

    Age (y)Tumor stageTNM classification
    StagenClassn
    <45I (any T, any N, M0)23T1 Nx8
    T1 N07
    T1 N13
    T2 NX1
    T2 N02
    T3 N02
    II (any T, any N, M1)1T3 N11
    >45I (T1, N0, M0)20T1 Nx16
    T1 N04
    II (T2, N0, M0)4T2 NX2
    T2 N02
    III (T3, N0, M0 or T1–3, N1a, M0)7T3 Nx2
    T3 N03
    T2 N1a1
    T3 N1a1
    IVA (T4a, N0–1a, M0 or T1–4, N1b, M0)1T3 N1b1
    IVB (T4b, any N, M0)0
    IVC (any T, any N, M1)1T3a N01
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    TABLE 2

    Planar Findings and SPECT/CT Characterization of Radioiodine-Positive Cervical Foci

    Planar findingsSPECT/CT characterizationNo. of lesions
    Lymph node metastasesLymph node metastases5
    Indeterminate1
    Thyroid remnant4
    Contamination1
    IndeterminateLymph node metastases4
    Thyroid remnant10
    Contamination1
    Thyroid remnantLymph node metastases7
    Thyroid remnant110
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Journal of Nuclear Medicine: 50 (1)
Journal of Nuclear Medicine
Vol. 50, Issue 1
January 2009
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Impact of 131I SPECT/Spiral CT on Nodal Staging of Differentiated Thyroid Carcinoma at the First Radioablation
Daniela Schmidt, Attila Szikszai, Rainer Linke, Werner Bautz, Torsten Kuwert
Journal of Nuclear Medicine Jan 2009, 50 (1) 18-23; DOI: 10.2967/jnumed.108.052746

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Impact of 131I SPECT/Spiral CT on Nodal Staging of Differentiated Thyroid Carcinoma at the First Radioablation
Daniela Schmidt, Attila Szikszai, Rainer Linke, Werner Bautz, Torsten Kuwert
Journal of Nuclear Medicine Jan 2009, 50 (1) 18-23; DOI: 10.2967/jnumed.108.052746
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Cited By...

  • SNMMI Procedure Standard/EANM Practice Guideline for Nuclear Medicine Evaluation and Therapy of Differentiated Thyroid Cancer: Abbreviated Version
  • I-131 Postablation SPECT/CT Predicts Relapse of Papillary Thyroid Carcinoma more Accurately than Whole Body Scan
  • ENDOCRINE TUMOURS: Imaging in the follow-up of differentiated thyroid cancer: current evidence and future perspectives for a risk-adapted approach
  • Radioiodine Scintigraphy with SPECT/CT: An Important Diagnostic Tool for Thyroid Cancer Staging and Risk Stratification
  • The SNMMI Practice Guideline for Therapy of Thyroid Disease with 131I 3.0
  • Radioiodine Scintigraphy with SPECT/CT: An Important Diagnostic Tool for Thyroid Cancer Staging and Risk Stratification
  • Postablation 131I scintigraphy with neck and thorax SPECT-CT and stimulated serum thyroglobulin level predict the outcome of patients with differentiated thyroid cancer
  • The Effect of Posttherapy 131I SPECT/CT on Risk Classification and Management of Patients with Differentiated Thyroid Cancer
  • The Significance of 99mTc-MAA SPECT/CT Liver Perfusion Imaging in Treatment Planning for 90Y-Microsphere Selective Internal Radiation Treatment
  • Single photon emission computed tomography (SPECT)/computed tomography using Iodine-123 in patients with differentiated thyroid cancer: additional value over whole body planar imaging and SPECT
  • Reply: Scintigraphic TNM Staging of Tumors: A Proposition
  • Scintigraphic TNM Staging of Tumors: A Proposition
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