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Figures
- FIGURE 1.
Synthesis of NOTA-RGD. Molar equivalents of c(RGDyK) and SCN-Bz-NOTA were allowed to react in sodium carbonate buffer (pH 9.5) for 20 h at room temperature.
- FIGURE 2.
Inhibition of 125I-c(RGDyK) binding to human αvβ3 integrin immobilized on PVC plates by c(RGDyK) and by NOTA-RGD. Ki values of c(RGDyK) and NOTA-RGD were 1.3 and 1.9 nM, respectively. Experiment was repeated 3 times in duplicate.
- FIGURE 3.
Biodistribution of 68Ga-NOTA-RGD without and with cold c(RGDyK) coinjection in mice with induced hind limb ischemia. Values represent mean %ID/g, and error bars represent SD.
- FIGURE 4.
Biodistribution of 68Ga-NOTA-RGD in mice bearing SNU-C4 xenografts at 1 h after injection through tail vein. Values represent mean %ID/g, and error bars represent SD.
- FIGURE 5.
Small-animal PET of 68Ga-NOTA-RGD injected into mice bearing SNU-C4 xenografts at 1 and 2 h after injection without cold c(RGDyK) (A) or with cold c(RGDyK) (60 μg) (B). Images at 1 h were taken before micturition, and images at 2 h were taken after micturition. Arrows indicate tumor positions. Acquisition time was 20 min.
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