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OtherBASIC SCIENCE INVESTIGATIONS

11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux

Sami S. Zoghbi, Jeih-San Liow, Fumihiko Yasuno, Jinsoo Hong, Edward Tuan, Neva Lazarova, Robert L. Gladding, Victor W. Pike and Robert B. Innis
Journal of Nuclear Medicine April 2008, 49 (4) 649-656; DOI: https://doi.org/10.2967/jnumed.107.047308
Sami S. Zoghbi
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Jeih-San Liow
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Fumihiko Yasuno
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Jinsoo Hong
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Edward Tuan
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Neva Lazarova
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Robert L. Gladding
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Victor W. Pike
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Robert B. Innis
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Article Information

vol. 49 no. 4 649-656
DOI 
https://doi.org/10.2967/jnumed.107.047308
PubMed 
18344435

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication September 13, 2007
  • Accepted for publication December 6, 2007
  • Published online March 28, 2008.

Article Versions

  • previous version (March 14, 2008 - 11:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2008 by Society of Nuclear Medicine

Author Information

  1. Sami S. Zoghbi,
  2. Jeih-San Liow,
  3. Fumihiko Yasuno,
  4. Jinsoo Hong,
  5. Edward Tuan,
  6. Neva Lazarova,
  7. Robert L. Gladding,
  8. Victor W. Pike and
  9. Robert B. Innis
  1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
  1. For correspondence or reprints contact: Sami S. Zoghbi, PhD, National Institute of Mental Health/National Institutes of Health, Molecular Imaging Branch, 31 Center Dr., Room B2-B37, MSC 2035, Bethesda, MD 20892-0135. E-mail: sami.zoghbi{at}nih.gov
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  • Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications
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    Clinical Pharmacology & Therapeutics 2009 86 4
  • P-Glycoprotein Function at the Blood–Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide
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  • Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function
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  • Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain Barrier
    Bernd Dörner, Claudia Kuntner, Jens P. Bankstahl, Marion Bankstahl, Johann Stanek, Thomas Wanek, Gloria Stundner, Severin Mairinger, Wolfgang Löscher, Markus Müller, Oliver Langer, Thomas Erker
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  • Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier
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Journal of Nuclear Medicine: 49 (4)
Journal of Nuclear Medicine
Vol. 49, Issue 4
April 2008
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11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux
Sami S. Zoghbi, Jeih-San Liow, Fumihiko Yasuno, Jinsoo Hong, Edward Tuan, Neva Lazarova, Robert L. Gladding, Victor W. Pike, Robert B. Innis
Journal of Nuclear Medicine Apr 2008, 49 (4) 649-656; DOI: 10.2967/jnumed.107.047308

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11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux
Sami S. Zoghbi, Jeih-San Liow, Fumihiko Yasuno, Jinsoo Hong, Edward Tuan, Neva Lazarova, Robert L. Gladding, Victor W. Pike, Robert B. Innis
Journal of Nuclear Medicine Apr 2008, 49 (4) 649-656; DOI: 10.2967/jnumed.107.047308
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  • Retrospective Analysis of P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
  • Behavioral Effects and Central Nervous System Levels of the Broadly Available {kappa}-Agonist Hallucinogen Salvinorin A Are Affected by P-Glycoprotein Modulation In Vivo
  • A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier
  • Avoiding Barriers to PET Radioligand Development: Cellular Assays of Brain Efflux Transporters
  • Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
  • PET Imaging of the Gastrointestinal Absorption of Orally Administered Drugs in Conscious and Anesthetized Rats
  • N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier
  • P-Glycoprotein Function at the Blood-Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide
  • Human Brain Imaging and Radiation Dosimetry of 11C-N-Desmethyl-Loperamide, a PET Radiotracer to Measure the Function of P-Glycoprotein
  • Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
  • P-Glycoprotein Function at the Blood-Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys
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