Article Figures & Data
Figures
- FIGURE 1.
Scan protocol and data preparation for 15O-gas PET. For cbOEF calculation, subsets of 15O2 dynamic data were extracted at 2, 3, 4, 5, 6, and 7 min (bars below diagram, from top to bottom, respectively) after beginning of 15O2 inhalation up to 13 min. cbOEF-AI was calculated from 15O2 images and H215O PET scans for 3 min. qOEF was calculated from 15O2 images obtained from 8 min to 13 min after 15O2 inhalation and H215O images with arterial blood data. C15O data were used for CBV correction of qOEF.
- FIGURE 2.
Changes in cbOEF-AI for 3 patients with misery perfusion, as determined from 15O2 images with various scan durations started at 2 min (A), 3 min (B), 4 min (C), and 5 min (D) after beginning of 15O2 inhalation. Misery perfusion was defined in our previous study as increase in qOEF of 52.0% or greater, which is equivalent to threshold of 1.17 for qOEF-AI (qOEF-AI = 1.17 for • and ▴ and 1.36 for ▪). Threshold of 1.15 for cbOEF-AI in present study (dashed line) was equivalent to threshold of 1.17 for qOEF-AI in our previous study. Regardless of different acquisition start times, continuous 15O2 inhalation for 7 min or longer would be required to correctly detect misery perfusion.
Tables
Value for: Parameter Ipsilateral hemisphere Contrateral hemisphere AI P* Cerebral blood flow (mL/min/100 g) 31.8 ± 4.94 34.7 ± 5.96 0.92 ± 0.09 <0.01 Cerebral metabolic rate for oxygen (mL/min/100 g) 2.21 ± 0.37 2.35 ± 0.42 0.94 ± 0.10 <0.01 OEF (%) 44.4 ± 6.0 43.3 ± 4.8 1.02 ± 0.06 <0.05 CBV (mL/100 g) 3.23 ± 0.88 3.18 ± 0.58 1.00 ± 0.13 0.30 ↵* As determined with paired t test.
- TABLE 2
Correlations Between qOEF-AI and cbOEF-AI for Different Acquisition Start Times and Scan Durations (n = 25)
Acquisition start time Scan duration (min) 2 min 3 min 4 min 5 min 6 min 7 min Slope r Bias Slope r Bias Slope r Bias Slope r Bias Slope r Bias Slope r Bias 1 0.73 0.79 2.5 1.14 0.92 2.7 1.14 0.95 2.0 0.86 0.93 1.7 0.81 0.90 1.9 0.81 0.94 1.8 2 0.98 0.93 2.1 1.09 0.96 1.7 1.05 0.96 1.5 0.84 0.96 1.2 0.81 0.94 1.7 0.93 0.96 1.4 3 1.00 0.95 1.6 0.94 0.95 1.6 0.93 0.97 1.2 0.83 0.96 1.2 0.90 0.97 1.3 0.92 0.96 1.3 4 0.90 0.94 1.5 0.89 0.96 1.2 0.89 0.97 1.0 0.92 0.98 1.0 0.91 0.97 1.2 0.95 0.98 1.0 5 0.87 0.96 1.3 0.89 0.97 1.0 0.91 0.98 1.0 0.93 0.98 1.0 0.93 0.98 0.8 0.95 0.98 0.7 6 0.86 0.97 1.1 0.92 0.98 0.9 0.92 0.98 1.0 0.98 0.99 0.7 0.94 0.98 0.8 1.01 0.98 0.8 7 0.89 0.98 1.0 0.92 0.98 0.9 0.96 0.99 0.7 0.99 0.99 0.7 0.99 0.99 0.7 8 0.90 0.99 0.8 0.94 0.99 0.7 0.95 0.99 0.7 1.04 0.99 0.8 9 0.91 0.99 0.7 0.94 0.99 0.6 1.00 0.99 0.6 10 0.91 0.99 0.6 0.97 0.99 0.6 11 0.95 0.99 0.6 Scan duration was time after beginning of 15O2 image scanning. Slope represents slope of regression line between qOEF-AI and cbOEF-AI. Bias represents mean distance between line of identity and plots of qOEF-AI and cbOEF-AI (%).
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