Article Figures & Data
Figures
- FIGURE 1.
Time–activity curves for total radioactivity (triangles) and for radioactivity corresponding to unmetabolized 2FA (circles) in smokers (open symbols) and nonsmokers (filled symbols), presented as SUV (fraction of injected dose/g of body weight absorbed in 1 g of tissue). Insert shows same data with expanded y-axis. Values are given as mean ± SEM.
- FIGURE 2.
Time–activity curves showing radioactivity corresponding to unmetabolized 2FA as fraction of total radioactivity in smokers (○) and nonsmokers (•). Values are given as mean ± SEM.
- FIGURE 3.
Representative time–activity curves for several brain regions in a nonsmoker (A) and a smoker (B) for thalamus (Th), frontal cortex (frCx), cerebellum (Cb), midbrain (Midbr), pons, putamen (Put), and corpus callosum (Cc). As expected, peak radioactivity expressed as SUV for regions assayed was greatest for thalamus > putamen = pons > midbrain > cerebellum = frontal cortex > > corpus callosum for nonsmokers. SUV for smokers revealed similar pattern, but peak values were greater.
- FIGURE 4.
Values for VT/fP for various brain regions in nonsmokers (A) and smokers (B). Values were obtained by Logan graphical analysis and 1- and 2-tissue-compartment models (1TCM and 2TCM, respectively). Values are given as mean ± SD. CC = corpus callosum; FrCx = frontal cortex; Cb = cerebellum; Put = putamen; Midbr = midbrain; Th = thalamus.
- FIGURE 5.
Values for differences between smokers and nonsmokers in VT/fP for same brain regions shown in Figure 4 obtained by Logan graphical analysis and 1- and 2-tissue-compartment models (1TCM and 2TCM, respectively). Values are given as mean ± SD. CC = corpus callosum; FrCx = frontal cortex; Cb = cerebellum; Put = putamen; Midbr = midbrain; Th = thalamus.
- FIGURE 6.
SPM comparison of smokers and nonsmokers: average parametric map of nonsmokers (control), average parametric map of smokers, and SPM comparison of smokers and nonsmokers. All panels show areas of brain in which VT/fP was greater for smokers than for nonsmokers. Opposite comparison yielded no areas in which VT/fP was greater for nonsmokers than for smokers. Minimum number of contiguous voxels for this analysis was 100. For images shown, total number of voxels tested was 190,993, and 17,980 were significant using a corrected P value of 0.01.
Tables
VS/fP VND/fP Frontal cortex Cerebellum Putamen Pons Midbrain Thalamus 3.5 197% 217% 172% 171% 179% 125% 4 220% 237% 185% 178% 186% 126% 4.5 258% 266% 202% 187% 196% 127% 5 330% 310% 228% 198% 207% 129% Data are differences in VS/fP in smokers, give as percentage of VS/fP in nonsmokers, for various values of VND/fP.
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