The need to study dynamic biologic processes in intact small-animal models has stimulated the development of high-resolution nuclear imaging methods. Above, small-animal SPECT/CT is applied to oncology research. In a prostate cancer xenograft model, radiolabeled antibodies for prostate-specific membrane antigen are used to monitor expression of the antigen. CT images and 3D rendering of fused images help define the tumor boundaries for more accurate image quantification.
See page 1651.