Microvascular Function in Viable Myocardium After Chronic Infarction Does Not Influence Fractional Flow Reserve Measurements

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
FIGURE 1.
(A) Plot of relationship between RFR as assessed by PET and RFR as assessed by FFR. (B) Bland–Altman plot of FFR and RFR. Solid line represents mean difference; dashed lines represent 2 SDs from this mean.
Download figure
Open in new tab
Download powerpoint
FIGURE 2.
Sensitivity and specificity curves for ability of FFR to detect ischemia by noninvasive stress testing.

TABLE 1

Clinical Characteristics of Patients (n = 27)

Parameter	Value
Age (y)	56 ± 9
Male (n)	23 (85%)
STEMI (n)	22 (81%)
Coronary risk factors (n)
Diabetes mellitus	2 (7%)
Hypertension	9 (33%)
Hypercholesterolemia	17 (63%)
Smoking	15 (56%)
Mean interval (±SD) between MI and PET (y)	3.3 ± 4.4
Infarct-related artery (n)
LAD	17 (63%)
LCx	3 (11%)
RCA	7 (26%)
Reference coronary artery (n)
LAD	4 (15%)
LCx	21 (78%)
RCA	2 (7%)
Left ventricular ejection fraction (%)	44 ± 15

STEMI = ST-segment elevation myocardial infarction; MI = myocardial infarction; LAD = left anterior descending artery; LCx = left circumflex artery; RCA = right coronary artery.

TABLE 2

Angiographic, Coronary Hemodynamic, and PET Data

Parameter	Value
DS infarct-related artery (%)	54 ± 25
FFR infarct-related artery	0.75 ± 0.16
FFR reference coronary artery	0.97 ± 0.02^*
hRPP during angiography (bpm·mm Hg)	7,849 ± 1,587
MBF infarcted area (mL/min/mL)
At baseline	0.73 ± 0.20
At hyperemia	2.21 ± 1.02
MBF reference area (mL/min/mL)
At baseline	0.89 ± 0.22^*
At hyperemia	2.92 ± 1.11^*
RFR	0.74 ± 0.18
hRPP during PET study (bpm·mm Hg)	8,479 ± 1,805

↵* P < 0.0001 for reference vs. infarcted area.
DS = diameter stenosis; hRPP = hyperemic rate–pressure product; MBF = myocardial blood flow.