This Month in JNM

Cardiac stem cell tracking: Zhang and Wu review the basic principles, current techniques, and future prospects for in vivo stem cell cardiovascular imaging.
Page 1916

PET/CT in pediatric malignancies: Federman and Feig offer the clinician's perspective on the status of functional/anatomic imaging in pediatric cancers and point to specific challenges, including the need for additional research and more refined protocols.
Page 1920

PET/CT in non-CNS pediatric cancers: Tatsumi and colleagues compare the accuracy and efficacy of PET/CT and conventional imaging in evaluating young patients with non–central nervous system malignancies.
Page 1923

PET/CT for Ewing tumors: Gerth and colleagues assess the relative advantages of PET/CT and PET alone in staging and restaging patients with Ewing tumor, with additional findings on the ability of the hybrid technique to detect new lesions.
Page 1932

¹⁸F-FDA PET in pheochromocytoma: Timmers and colleagues report on patient studies designed to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake in 6-¹⁸F-fluorodopamine PET localization of pheochromocytoma.
Page 1940

¹⁸F-FLT PET in gastric cancer: Herrmann and colleagues evaluate the proliferation marker ¹⁸F-fluorothymidine for PET detection of gastric cancer and compare the resulting diagnostic accuracy with that of ¹⁸F-FDG PET.
Page 1945

Variable patient size and PET: El Fakhri and colleagues assess whole-body ¹⁸F-FDG PET performance in lesion detection using a series of different acquisition and processing methods adjusted for patients of varying sizes and weights.
Page 1951

Metabolism vs. morphometry in AD: Matsunari and colleagues compare the abilities of ¹⁸F-FDG PET and optimized voxel-based morphometry in discriminating between healthy individuals and those at progressive stages of Alzheimer's disease.
Page 1961

¹¹C-Met PET normal references: Coope and colleagues describe coregistration methods to facilitate interpretation of ¹¹C-methionine PET images with reference to averaged normal uptake maps, allowing standardization of analysis and increased sensitivity to tumor infiltration.
Page 1971

D₂ receptors and iNPH: Nakayama and colleagues use ¹¹C-raclopride PET to extend their studies of idiopathic normal pressure hydrocephalus, focusing on treatment with ventriculoperitoneal shunts and the contributions of dopamine receptors to associated pathophysiology.
Page 1981

Microvascular resistance in chronic infarct areas: Marques and colleagues report on an H₂¹⁵O PET study comparing fractional flow reserve in infarct-related arteries and reference flow reserve in patients with chronic myocardial infarction.
Page 1987

Spironolactone and candesartan in CHF: Kasama and colleagues investigate the effects of the angiotensin-receptor blocker candesartan alone and in combination with spironolactone in cardiac sympathetic nerve activity and left ventricular function in patients with congestive heart failure.
Page 1993

Nuclear imaging in CRT: Henneman and colleagues provide an educational overview of the status of cardiac resynchronization therapy in heart failure, including a review of nuclear medicine techniques in initial assessment, evaluation of therapy, and prediction of outcomes.
Page 2001

Imaging mesenchymal stem cells: Love and colleagues describe a triple-reporter system for bioluminescence and PET imaging to monitor human mesenchymal stem cell transplants and discuss the potential for translation to human studies with PET.
Page 2011

¹⁸F-F-CP PET for breast cancer: Kesner and colleagues examine the biodistribution of ¹⁸F-fluorocyclophosphamide in mice bearing human breast cancer xenografts and report on the potential of this technique in predicting the resistance of tumors to cyclophosphamide therapy.
Page 2021

Antisense imaging: Liu and colleagues investigate whether a ^99mTc-radiolabeled antisense oligonucleotide targeting human telomerase reverse transcriptase mRNA can be used for in vivo imaging of telomerase activity in carcinomas.
Page 2028

Math model of dynamic ¹⁸F-FDG PET data: Ferl and colleagues report on a novel method for plasma time–activity curve estimation in murine small-animal PET studies, based on a model of tracer kinetics in blood, muscle, and liver.
Page 2037

¹¹C-lactate PET and myocardial imaging: Herrero and colleagues use l-3-¹¹C-lactate PET to acquire noninvasive quantitative measurements of myocardial lactate metabolism in animals.
Page 2046

Tracer uptake in brain abscesses: Salber and colleagues compare uptake of the amino acid tracer ¹⁸F-FET with that of ³H-MET and ³H-DG in brain abscesses in rats to assess the suitability of ¹⁸F-FET imaging for distinguishing between inflammation and gliomas.
Page 2056

LAT-mediated amino acid uptake in tumors: Haase and colleagues provide evidence that ¹⁸F-labeled amino acids that accumulate in tumors via system L amino acid transporters represent an important class of imaging agents for in vivo PET visualization of tumors.
Page 2063

Radiation dosimetry of ¹¹C-PBR28: Brown and colleagues report on studies estimating human radiation doses for this recently developed radioligand, which shows promise in imaging peripheral benzodiazepine receptors.
Page 2072

Radiation safety with ⁹⁰Y-microspheres: Gulec and Siegel describe radiation safety issues associated with the intrahepatic arterial administration of ⁹⁰Y-resin or ⁹⁰Y-glass microspheres, including dose estimates and posttherapy management.
Page 2080

ON THE COVER

This schematic for the noninvasive imaging of stem cell fate in myocardium shows the 4 different techniques currently in use for tracking stell cells in vivo, including magnetic particle labeling, radionuclide labeling, quantum dot labeling, and reporter gene labeling.

See page 1917.