OtherFOCUS ON MOLECULAR IMAGING

Comparison of Imaging Techniques for Tracking Cardiac Stem Cell Therapy

Sarah J. Zhang and Joseph C. Wu
Journal of Nuclear Medicine December 2007, 48 (12) 1916-1919; DOI: https://doi.org/10.2967/jnumed.107.043299

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    Schematic for noninvasive imaging of stem cell fate in myocardium. The 4 different techniques include magnetic particle labeling, radionuclide labeling, QD labeling, and reporter gene labeling. SPIO = superparamagnetic iron oxide; IFP = iron fluorescent particles.

  • FIGURE 2. 
    FIGURE 2. 
    FIGURE 2. 
    FIGURE 2. 
    FIGURE 2. 

    MRI of transplanted cardiac stem cells in pigs. (A and B) Long-axis view of left ventricle before (A) and after (B) transcatheter injection of 4 × 106 iron fluorescent particle (IFP)–labeled mesenchymal stem cells (MSCs) into infarct at apex (arrows) and into adjoining normal myocardium (arrowhead). (C and D) Long-axis view with delayed, hyperenhanced inversion recovery highlights areas of nonviable infarcted myocardium before (C) and after (D) injection of IFP-labeled MSCs. MSCs appear dark against hyperenhanced infarct. (Reprinted with permission from (10).)

  • FIGURE 3. 
    FIGURE 3. 
    FIGURE 3. 
    FIGURE 3. 
    FIGURE 3. 

    Evaluation of myocardial homing and biodistribution of 18F-FDG–labeled bone marrow cells after intracoronary delivery in patient after myocardial infarction. (A and B) Representative left posterior oblique (A) and left anterior oblique (B) views at 65 min after injection of 18F-FDG–labeled unselected bone marrow cells into the left circumflex coronary artery. (C and D) Representative left posterior oblique (C) and left anterior oblique (D) views at 70 min after injection of 18F-FDG–labeled CD34-positive subpopulation of bone marrow cells into left anterior descending coronary artery. (Reprinted with permission from (17).)

  • FIGURE 4. 
    FIGURE 4. 

    Tracking of transplanted embryonic stem cells in rats by multimodality molecular imaging. (A) Bioluminescence imaging (top) and small-animal PET (bottom) of embryonic stem cell fate in living animals. Representative images demonstrate imaging signal activities in these mouse embryonic stem cells that stably express firefly luciferase (bioluminescence imaging), monomeric red fluorescence protein (fluorescence), and herpes simplex virus truncated thymidine kinase (PET) triple-fusion reporter gene. (B) Significant increase of firefly luciferase and truncated thymidine kinase activities were seen from week 2 to week 4, indicative of in vivo teratoma formation. (C) In vivo correlation between bioluminescence and PET imaging signals. BLI = bioluminescence imaging; d = day; P = photons; sr = steridian; tTk = truncated thymidine kinase; w = week. (Reprinted with permission from (24).)

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