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Journal of Nuclear Medicine

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OtherBASIC SCIENCE INVESTIGATIONS

Quantitative Analysis of 11C-Verapamil Transfer at the Human Blood–Brain Barrier for Evaluation of P-glycoprotein Function

Yoko Ikoma, Akihiro Takano, Hiroshi Ito, Hiroyuki Kusuhara, Yuichi Sugiyama, Ryosuke Arakawa, Toshimitsu Fukumura, Ryuji Nakao, Kazutoshi Suzuki and Tetsuya Suhara
Journal of Nuclear Medicine September 2006, 47 (9) 1531-1537;
Yoko Ikoma
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Akihiro Takano
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Hiroshi Ito
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Hiroyuki Kusuhara
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Yuichi Sugiyama
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Ryosuke Arakawa
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Toshimitsu Fukumura
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Ryuji Nakao
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Kazutoshi Suzuki
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Tetsuya Suhara
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FIGURE 2. 

FIGURE 2. 
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FIGURE 2. 

Time curve of percentage of unchanged radioligand and metabolites in total plasma radioactivity using 11C-verapamil in 10 subjects.

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Journal of Nuclear Medicine: 66 (6)
Journal of Nuclear Medicine
Vol. 66, Issue 6
June 1, 2025
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Quantitative Analysis of 11C-Verapamil Transfer at the Human Blood–Brain Barrier for Evaluation of P-glycoprotein Function
Yoko Ikoma, Akihiro Takano, Hiroshi Ito, Hiroyuki Kusuhara, Yuichi Sugiyama, Ryosuke Arakawa, Toshimitsu Fukumura, Ryuji Nakao, Kazutoshi Suzuki, Tetsuya Suhara
Journal of Nuclear Medicine Sep 2006, 47 (9) 1531-1537;

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Quantitative Analysis of 11C-Verapamil Transfer at the Human Blood–Brain Barrier for Evaluation of P-glycoprotein Function
Yoko Ikoma, Akihiro Takano, Hiroshi Ito, Hiroyuki Kusuhara, Yuichi Sugiyama, Ryosuke Arakawa, Toshimitsu Fukumura, Ryuji Nakao, Kazutoshi Suzuki, Tetsuya Suhara
Journal of Nuclear Medicine Sep 2006, 47 (9) 1531-1537;
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Cited By...

  • Avoiding Barriers to PET Radioligand Development: Cellular Assays of Brain Efflux Transporters
  • Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
  • Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans
  • Human Brain Imaging and Radiation Dosimetry of 11C-N-Desmethyl-Loperamide, a PET Radiotracer to Measure the Function of P-Glycoprotein
  • Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Studied with (R)-11C-Verapamil and PET
  • Evaluation of In Vivo P-Glycoprotein Function at the Blood-Brain Barrier Among MDR1 Gene Polymorphisms by Using 11C-Verapamil
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